75408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4685540..4686131 Replicon chromosome
Accession NZ_CP020771
Organism Microcystis aeruginosa PCC 7806SL

Toxin (Protein)


Gene name PumA Uniprot ID A0A1X9LFN9
Locus tag BH695_RS23285 Protein ID WP_002740647.1
Coordinates 4685540..4685830 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1X9LDY9
Locus tag BH695_RS23290 Protein ID WP_002740648.1
Coordinates 4685841..4686131 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH695_RS23270 4680836..4682767 + 1932 WP_002740639.1 glycine oxidase ThiO -
BH695_RS23275 4682783..4683574 + 792 WP_002740641.1 class I SAM-dependent methyltransferase -
BH695_RS23280 4683760..4685295 - 1536 WP_002740645.1 TolC family protein -
BH695_RS23285 4685540..4685830 + 291 WP_002740647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BH695_RS23290 4685841..4686131 + 291 WP_002740648.1 putative addiction module antidote protein Antitoxin
BH695_RS23295 4686128..4687672 - 1545 WP_002740650.1 gamma-glutamyltransferase -
BH695_RS23300 4687837..4688868 - 1032 WP_084990090.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
BH695_RS23305 4689710..4690735 + 1026 WP_084990141.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11039.64 Da        Isoelectric Point: 10.0164

>T75408 WP_002740647.1 NZ_CP020771:4685540-4685830 [Microcystis aeruginosa PCC 7806SL]
MIEIRQTETYSEWFSALRDHQAKARINIRIRRLSMGNPGDVKPVGRGVSELRVDYGPGYRVYFKQQGETLIILLAGGDKR
TQERDIKTALDLAQYL

Download         Length: 291 bp

>T75408 NZ_CP020771:4685540-4685830 [Microcystis aeruginosa PCC 7806SL]
ATGATTGAAATTCGCCAGACCGAAACCTATTCTGAGTGGTTTAGTGCTTTGCGAGATCATCAGGCCAAGGCACGCATAAA
TATCCGCATTCGTCGTTTATCTATGGGCAATCCGGGTGATGTTAAGCCAGTAGGACGAGGTGTATCGGAACTGCGCGTTG
ATTATGGACCGGGCTATCGCGTGTATTTCAAACAACAAGGTGAGACTTTGATTATTCTCTTGGCGGGGGGAGACAAACGG
ACTCAAGAACGGGACATCAAAACAGCATTAGATTTAGCCCAATACTTATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10375.89 Da        Isoelectric Point: 5.0348

>AT75408 WP_002740648.1 NZ_CP020771:4685841-4686131 [Microcystis aeruginosa PCC 7806SL]
MATIQTYPWDAADHLKTKEDIAAYLEAALEDGDPSLVVAALGDIARSQGMTHIARETGLGRESLYKSLSNRGNPEFATVL
KVLQALGLRLQVVPII

Download         Length: 291 bp

>AT75408 NZ_CP020771:4685841-4686131 [Microcystis aeruginosa PCC 7806SL]
ATGGCTACAATTCAGACTTATCCTTGGGATGCAGCAGATCATTTGAAAACAAAAGAAGATATCGCCGCTTATCTGGAAGC
TGCCCTCGAAGATGGCGATCCTAGCTTAGTAGTGGCAGCATTAGGTGATATAGCTCGTTCTCAAGGGATGACTCATATTG
CTCGCGAGACGGGTTTGGGACGGGAGAGTCTCTATAAATCTTTGTCGAATCGGGGTAATCCAGAGTTTGCTACAGTTCTT
AAGGTTTTGCAAGCACTTGGGTTACGCCTGCAAGTTGTACCCATTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9LFN9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X9LDY9

References