Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 3930369..3931228 Replicon chromosome
Accession NZ_CP020771
Organism Microcystis aeruginosa PCC 7806SL

Toxin (Protein)


Gene name hepT Uniprot ID A0A1X9LDD0
Locus tag BH695_RS19480 Protein ID WP_002742889.1
Coordinates 3930369..3930767 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A1X9LBQ1
Locus tag BH695_RS19485 Protein ID WP_002742890.1
Coordinates 3930809..3931228 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BH695_RS19470 3926250..3929696 - 3447 WP_002742886.1 type I-D CRISPR-associated protein Cas10d/Csc3 -
BH695_RS26340 3929689..3929914 - 226 Protein_3701 DUF86 domain-containing protein -
BH695_RS19475 3929918..3930376 - 459 WP_036400372.1 nucleotidyltransferase domain-containing protein -
BH695_RS19480 3930369..3930767 - 399 WP_002742889.1 DUF86 domain-containing protein Toxin
BH695_RS19485 3930809..3931228 - 420 WP_002742890.1 nucleotidyltransferase domain-containing protein Antitoxin
BH695_RS19490 3931391..3931738 - 348 WP_002742891.1 hypothetical protein -
BH695_RS19495 3932084..3932326 - 243 WP_002742893.1 hypothetical protein -
BH695_RS19500 3932373..3934538 - 2166 WP_084990033.1 type I-D CRISPR-associated helicase Cas3' -
BH695_RS19505 3934637..3935500 + 864 WP_002742899.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(1-117)

Antitoxin

Polymerase beta, nucleotidyltransferase

(6-101)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15324.59 Da        Isoelectric Point: 4.6345

>T75407 WP_002742889.1 NZ_CP020771:c3930767-3930369 [Microcystis aeruginosa PCC 7806SL]
MNQYLAELSEYGSITLEDYRTLRERQLAIERLIQLIIQTGIDINYQILKCLDIESPNNARDALFQIVELGILEEHLAVQL
AESIKLRNLLVHLYKKIDPDIVHSSIANILRDYPRYQRSIVQFLDSLEAENG

Download         Length: 399 bp

>T75407 NZ_CP020771:c3930767-3930369 [Microcystis aeruginosa PCC 7806SL]
ATGAATCAATACCTCGCCGAACTTAGCGAGTACGGTTCGATCACCTTAGAGGATTATCGTACATTAAGAGAACGTCAATT
AGCCATAGAAAGGTTAATTCAGCTTATCATTCAAACTGGCATCGATATCAATTACCAGATTTTAAAATGTTTAGATATCG
AGTCTCCGAATAATGCTCGCGACGCATTATTTCAGATCGTAGAACTGGGAATTTTAGAAGAACACCTAGCCGTTCAACTG
GCCGAGTCTATTAAATTAAGAAACTTACTCGTACACCTATACAAGAAAATTGATCCCGATATTGTTCATTCCTCGATCGC
TAATATTTTACGAGATTATCCTCGCTACCAACGCTCGATCGTTCAATTTCTAGATTCCTTGGAGGCAGAAAATGGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 16307.78 Da        Isoelectric Point: 5.1063

>AT75407 WP_002742890.1 NZ_CP020771:c3931228-3930809 [Microcystis aeruginosa PCC 7806SL]
MNRLVEKITAIVEKLPNLKLLILFGSRARREHRPDSDWDFAVLYEERSDQKDISSLLKIYTLLEQALEIPEDKIDVVDLK
ECSPILAHYVARDGQLLYERETGLFEGFKEKFLMNPEESKALYRQLRNNLEISLREKGV

Download         Length: 420 bp

>AT75407 NZ_CP020771:c3931228-3930809 [Microcystis aeruginosa PCC 7806SL]
ATGAATAGGCTAGTAGAAAAAATTACGGCTATTGTCGAAAAACTACCGAATTTAAAACTATTAATTCTCTTCGGTTCTAG
AGCGCGTAGAGAGCATAGACCTGATAGCGATTGGGATTTCGCTGTTTTATACGAGGAAAGAAGCGATCAAAAGGATATTT
CGAGTCTGTTGAAAATTTATACACTGCTCGAACAAGCTTTAGAGATTCCCGAGGACAAAATTGATGTGGTTGATTTAAAA
GAATGTTCGCCGATCCTCGCTCATTATGTCGCACGGGATGGTCAACTTCTATACGAACGGGAAACGGGACTATTCGAGGG
ATTTAAAGAAAAATTTCTCATGAATCCTGAAGAATCGAAAGCGTTATACCGTCAATTACGGAATAATCTAGAGATTTCTC
TACGAGAAAAAGGAGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9LDD0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X9LBQ1

References