Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 242443..243085 Replicon chromosome
Accession NZ_CP020743
Organism Bacillus mycoides strain Gnyt1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag B7492_RS01375 Protein ID WP_000635965.1
Coordinates 242735..243085 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag B7492_RS01370 Protein ID WP_000004570.1
Coordinates 242443..242730 (+) Length 96 a.a.

Genomic Context

B7492_RS01345B7492_RS01355B7492_RS01360B7492_RS01365B7492_RS01370B7492_RS01375B7492_RS01380B7492_RS01390B7492_RS01350B7492_RS01385
Location: 237759..238721 (963 bp)
Type: Others
Protein ID: WP_002029436.1
Location: 239378..239737 (360 bp)
Type: Others
Protein ID: WP_002009969.1
Location: 239894..240844 (951 bp)
Type: Others
Protein ID: WP_002124820.1
Location: 240962..242131 (1170 bp)
Type: Others
Protein ID: WP_085308684.1
Location: 242443..242730 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 242735..243085 (351 bp)
Type: Toxin
Protein ID: WP_000635965.1
Location: 243154..245322 (2169 bp)
Type: Others
Protein ID: WP_085312924.1
Location: 245707..246162 (456 bp)
Type: Others
Protein ID: WP_016095131.1
Location: 238714..239286 (573 bp)
Type: Others
Protein ID: WP_002167128.1
Location: 245380..245496 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B7492_RS01345237759..238721+963WP_002029436.1UV DNA damage repair endonuclease UvsE-
B7492_RS01350238714..239286-573WP_002167128.1rhomboid family intramembrane serine protease-
B7492_RS01355239378..239737+360WP_002009969.1holo-ACP synthase-
B7492_RS01360239894..240844+951WP_002124820.1outer membrane lipoprotein carrier protein LolA-
B7492_RS01365240962..242131+1170WP_085308684.1alanine racemase-
B7492_RS01370242443..242730+288WP_000004570.1antitoxin EndoAIAntitoxin
B7492_RS01375242735..243085+351WP_000635965.1type II toxin-antitoxin system endoribonuclease NdoAToxin
B7492_RS01380243154..245322+2169WP_085312924.1RNA-binding transcriptional accessory protein-
B7492_RS01385245380..245496-117WP_001143642.1cortex morphogenetic protein CmpA-
B7492_RS01390245707..246162+456WP_016095131.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T75374 WP_000635965.1 NZ_CP020743:242735-243085 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T75374 NZ_CP020743:242735-243085 [Bacillus mycoides]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGGGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT75374 WP_000004570.1 NZ_CP020743:242443-242730 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT75374 NZ_CP020743:242443-242730 [Bacillus mycoides]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A366G118

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References