Detailed information of TA system TA075373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1861492..1861988
• Replicon: chromosome
• Accession: NZ_CP020742
• Organism: Bartonella henselae strain Houston-I

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: BhenCHDE101_RS08400
• Protein ID: WP_197536999.1
• Coordinates: 1861749..1861988 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: BhenCHDE101_RS08395
• Protein ID: WP_034448465.1
• Coordinates: 1861492..1861701 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BhenCHDE101_RS08375	1856993..1857493	-	501	Protein_1491	transcriptional regulator	-
BhenCHDE101_RS08380	1858142..1858813	-	672	WP_011181356.1	VUT family protein	-
BhenCHDE101_RS08385	1858927..1859220	-	294	WP_011181357.1	50S ribosomal protein L28	-
BhenCHDE101_RS08390	1859499..1860284	+	786	WP_011181358.1	SURF1 family protein	-
BhenCHDE101_RS08395	1861492..1861701	+	210	WP_034448465.1	hypothetical protein	Antitoxin
BhenCHDE101_RS08400	1861749..1861988	+	240	WP_197536999.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BhenCHDE101_RS09080	1862214..1862370	+	157	Protein_1497	DUF4102 domain-containing protein	-
BhenCHDE101_RS08910	1864026..1864127	-	102	WP_157774295.1	DUF1127 domain-containing protein	-
BhenCHDE101_RS08410	1864408..1866024	-	1617	WP_011181360.1	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-75)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9317.94 Da
• Isoelectric Point: 10.0545

>T75373 WP_197536999.1 NZ_CP020742:1861749-1861988 [Bartonella henselae]
ILSYIARENPFAARRMKKQLEASVLPLSEHPYLYQKSERVLKLREIVAHPNYLILYQVTVNQIEIVTVVHTRREFPVSL

Nucleotide

• Length: 240 bp

>T75373 NZ_CP020742:1861749-1861988 [Bartonella henselae]
ATTTTATCTTACATTGCTCGTGAAAATCCATTTGCTGCGCGACGAATGAAAAAACAGCTGGAAGCGTCCGTGTTACCTTT
ATCCGAGCATCCATATTTGTATCAAAAAAGTGAAAGAGTATTAAAGCTAAGAGAAATTGTAGCCCATCCAAATTATCTTA
TATTGTATCAAGTGACCGTAAATCAAATTGAGATTGTTACTGTAGTACATACTCGGCGTGAGTTTCCTGTTTCTCTGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7954.96 Da
• Isoelectric Point: 4.3201

>AT75373 WP_034448465.1 NZ_CP020742:1861492-1861701 [Bartonella henselae]
IHDQYKGKTAFSLLVSEFEIAEQELSYTDWLRNKVAKSLANLHPVIPHDEVMAEMEAVRDQIVAEQEEL

Nucleotide

• Length: 210 bp

>AT75373 NZ_CP020742:1861492-1861701 [Bartonella henselae]
ATCCATGATCAATATAAAGGAAAGACTGCTTTTTCTCTACTCGTTTCAGAATTTGAAATAGCCGAGCAGGAACTTAGTTA
TACTGATTGGTTGCGTAACAAGGTAGCAAAGAGTCTTGCTAATCTGCATCCTGTCATTCCGCATGACGAGGTTATGGCTG
AAATGGAAGCGGTAAGAGATCAGATTGTCGCCGAGCAGGAAGAGTTGTAG