Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-parD/RelE-RHH |
| Location | 1033641..1034200 | Replicon | chromosome |
| Accession | NZ_CP020742 | ||
| Organism | Bartonella henselae strain Houston-I | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M706 |
| Locus tag | BhenCHDE101_RS04625 | Protein ID | WP_011180615.1 |
| Coordinates | 1033928..1034200 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | X5LVL8 |
| Locus tag | BhenCHDE101_RS04620 | Protein ID | WP_011180616.1 |
| Coordinates | 1033641..1033931 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BhenCHDE101_RS04570 | 1029576..1029902 | - | 327 | WP_011180626.1 | hypothetical protein | - |
| BhenCHDE101_RS04580 | 1030201..1030659 | + | 459 | WP_011180624.1 | hypothetical protein | - |
| BhenCHDE101_RS04590 | 1031177..1031446 | - | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BhenCHDE101_RS04595 | 1031430..1031657 | - | 228 | WP_007346764.1 | ribbon-helix-helix protein, CopG family | - |
| BhenCHDE101_RS04600 | 1031765..1032097 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| BhenCHDE101_RS04605 | 1032097..1032354 | - | 258 | WP_034448603.1 | antitoxin | - |
| BhenCHDE101_RS04610 | 1032435..1032929 | - | 495 | WP_059443338.1 | hypothetical protein | - |
| BhenCHDE101_RS04615 | 1032983..1033429 | - | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| BhenCHDE101_RS04620 | 1033641..1033931 | + | 291 | WP_011180616.1 | hypothetical protein | Antitoxin |
| BhenCHDE101_RS04625 | 1033928..1034200 | + | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| BhenCHDE101_RS04630 | 1034388..1034708 | - | 321 | Protein_863 | hypothetical protein | - |
| BhenCHDE101_RS04635 | 1034890..1035276 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| BhenCHDE101_RS04640 | 1035260..1036510 | - | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| BhenCHDE101_RS04645 | 1036500..1036979 | - | 480 | WP_011180611.1 | hypothetical protein | - |
| BhenCHDE101_RS04650 | 1037116..1037475 | - | 360 | WP_011180610.1 | hypothetical protein | - |
| BhenCHDE101_RS04655 | 1037565..1037768 | - | 204 | Protein_868 | hypothetical protein | - |
| BhenCHDE101_RS04660 | 1037994..1038263 | + | 270 | WP_099358259.1 | hypothetical protein | - |
| BhenCHDE101_RS04665 | 1038502..1038876 | + | 375 | WP_011180607.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1005272..1045394 | 40122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10747.75 Da Isoelectric Point: 11.3976
>T75372 WP_011180615.1 NZ_CP020742:1033928-1034200 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
Download Length: 273 bp
>T75372 NZ_CP020742:1033928-1034200 [Bartonella henselae]
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 11099.43 Da Isoelectric Point: 4.5837
>AT75372 WP_011180616.1 NZ_CP020742:1033641-1033931 [Bartonella henselae]
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
Download Length: 291 bp
>AT75372 NZ_CP020742:1033641-1033931 [Bartonella henselae]
ATGGCTGAAACAACATTTACCTTTCGCGTTGATGATGCATTAAAAAGTGAATTTTCTCAGGCTGCAAAAGCATGTGATCG
ATCTGCTGCACAGCTCTTACGGGATTACATGCGTGATATTGTAAAAGAACAAAAAGAAAAGATAGCGCATGAATTATGGT
TTCAGGAACAAGTCCAACTTGGATTAAATTCTGCCAACGCAGGTGATGTAATACCTTTTGAAGAAATTGAAACAGAAGCA
CAAGCATGGCGCTTTGAAATACAACGCAAGCTGAAGACATCAGATTCATGA
ATGGCTGAAACAACATTTACCTTTCGCGTTGATGATGCATTAAAAAGTGAATTTTCTCAGGCTGCAAAAGCATGTGATCG
ATCTGCTGCACAGCTCTTACGGGATTACATGCGTGATATTGTAAAAGAACAAAAAGAAAAGATAGCGCATGAATTATGGT
TTCAGGAACAAGTCCAACTTGGATTAAATTCTGCCAACGCAGGTGATGTAATACCTTTTGAAGAAATTGAAACAGAAGCA
CAAGCATGGCGCTTTGAAATACAACGCAAGCTGAAGACATCAGATTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4L5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W521 |