Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1031765..1032354 Replicon chromosome
Accession NZ_CP020742
Organism Bartonella henselae strain Houston-I

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag BhenCHDE101_RS04600 Protein ID WP_011180620.1
Coordinates 1031765..1032097 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A829Z4P4
Locus tag BhenCHDE101_RS04605 Protein ID WP_034448603.1
Coordinates 1032097..1032354 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BhenCHDE101_RS04565 1028270..1029595 - 1326 WP_011180823.1 phage terminase large subunit -
BhenCHDE101_RS04570 1029576..1029902 - 327 WP_011180626.1 hypothetical protein -
BhenCHDE101_RS04580 1030201..1030659 + 459 WP_011180624.1 hypothetical protein -
BhenCHDE101_RS04590 1031177..1031446 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
BhenCHDE101_RS04595 1031430..1031657 - 228 WP_007346764.1 ribbon-helix-helix protein, CopG family -
BhenCHDE101_RS04600 1031765..1032097 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BhenCHDE101_RS04605 1032097..1032354 - 258 WP_034448603.1 antitoxin Antitoxin
BhenCHDE101_RS04610 1032435..1032929 - 495 WP_059443338.1 hypothetical protein -
BhenCHDE101_RS04615 1032983..1033429 - 447 WP_011180617.1 single-stranded DNA-binding protein -
BhenCHDE101_RS04620 1033641..1033931 + 291 WP_011180616.1 hypothetical protein -
BhenCHDE101_RS04625 1033928..1034200 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
BhenCHDE101_RS04630 1034388..1034708 - 321 Protein_863 hypothetical protein -
BhenCHDE101_RS04635 1034890..1035276 - 387 WP_082246570.1 hypothetical protein -
BhenCHDE101_RS04640 1035260..1036510 - 1251 WP_011180612.1 DUF1376 domain-containing protein -
BhenCHDE101_RS04645 1036500..1036979 - 480 WP_011180611.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1005272..1045394 40122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T75371 WP_011180620.1 NZ_CP020742:c1032097-1031765 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T75371 NZ_CP020742:c1032097-1031765 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9381.71 Da        Isoelectric Point: 4.2101

>AT75371 WP_034448603.1 NZ_CP020742:c1032354-1032097 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL

Download         Length: 258 bp

>AT75371 NZ_CP020742:c1032354-1032097 [Bartonella henselae]
ATGCACACAACAAAATTACGTAAAGTTGGAGGGTCTGTTATGCTCTCTATACCGCCGGCATTGCTTGATGTTCTTCATCT
TACTGAGAACACGCAAGTTGGTTTGGCTGTTGATAATGGACAATTGGTTGTGAAGCCACAGACATTTCCAAGTTACACTC
TTGATGAATTGTTAGCTCAATGTAATCCTTCAGATGATTTTGCGGATGAGGATATGGAGTGGTTTGATGCTAAACCTGTT
GGTAGAGAGCTCTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4K9

Antitoxin

Source ID Structure
AlphaFold DB A0A829Z4P4

References