Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 436900..437492 | Replicon | chromosome |
| Accession | NZ_CP020742 | ||
| Organism | Bartonella henselae strain Houston-I | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | BhenCHDE101_RS01865 | Protein ID | WP_034447446.1 |
| Coordinates | 437292..437492 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | BhenCHDE101_RS01860 | Protein ID | WP_011180290.1 |
| Coordinates | 436900..437295 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BhenCHDE101_RS01820 | 432165..432923 | - | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| BhenCHDE101_RS01825 | 432983..433498 | - | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| BhenCHDE101_RS01830 | 433791..434354 | - | 564 | Protein_346 | antA/AntB antirepressor family protein | - |
| BhenCHDE101_RS01835 | 434386..434928 | - | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| BhenCHDE101_RS01850 | 435525..436103 | - | 579 | WP_011180287.1 | hypothetical protein | - |
| BhenCHDE101_RS01855 | 436107..436427 | - | 321 | WP_011180288.1 | hypothetical protein | - |
| BhenCHDE101_RS01860 | 436900..437295 | - | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| BhenCHDE101_RS01865 | 437292..437492 | - | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| BhenCHDE101_RS01870 | 437557..438093 | - | 537 | WP_034447444.1 | hypothetical protein | - |
| BhenCHDE101_RS01875 | 438104..438550 | - | 447 | WP_011180293.1 | single-stranded DNA-binding protein | - |
| BhenCHDE101_RS01880 | 438741..439022 | + | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BhenCHDE101_RS01885 | 439039..439332 | + | 294 | WP_034447441.1 | HigA family addiction module antidote protein | - |
| BhenCHDE101_RS01890 | 439374..439700 | - | 327 | WP_034447437.1 | hypothetical protein | - |
| BhenCHDE101_RS01895 | 439865..440284 | - | 420 | WP_038525124.1 | hypothetical protein | - |
| BhenCHDE101_RS01900 | 440277..441389 | - | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| BhenCHDE101_RS01905 | 441379..441726 | - | 348 | WP_011180298.1 | DUF1376 domain-containing protein | - |
| BhenCHDE101_RS01910 | 441719..442195 | - | 477 | WP_011180299.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 386552..456213 | 69661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T75368 WP_034447446.1 NZ_CP020742:c437492-437292 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T75368 NZ_CP020742:c437492-437292 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT75368 WP_011180290.1 NZ_CP020742:c437295-436900 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT75368 NZ_CP020742:c437295-436900 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |