Detailed information of TA system TA075357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 893732..894264
• Replicon: chromosome
• Accession: NZ_CP020741
• Organism: Staphylococcus aureus strain HZW450

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: B7437_RS04420
• Protein ID: WP_001103942.1
• Coordinates: 893944..894264 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: B7437_RS04415
• Protein ID: WP_001058486.1
• Coordinates: 893732..893941 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7437_RS04370	888752..889972	-	1221	WP_000266157.1	site-specific integrase	-
B7437_RS04375	890060..890788	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
B7437_RS04380	890812..891540	-	729	WP_001033318.1	staphylococcal enterotoxin type Q	-
B7437_RS04385	891610..892041	-	432	WP_001228759.1	hypothetical protein	-
B7437_RS04390	892058..892516	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
B7437_RS04395	892528..892860	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
B7437_RS04400	893053..893316	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
B7437_RS04405	893309..893581	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
B7437_RS04410	893593..893739	+	147	WP_000784875.1	hypothetical protein	-
B7437_RS04415	893732..893941	+	210	WP_001058486.1	hypothetical protein	Antitoxin
B7437_RS04420	893944..894264	+	321	WP_001103942.1	DUF1474 family protein	Toxin
B7437_RS04425	894328..895197	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
B7437_RS04430	895214..896683	+	1470	WP_000390454.1	virulence-associated E family protein	-
B7437_RS04440	896969..897331	+	363	WP_001039168.1	hypothetical protein	-
B7437_RS04445	897333..897617	+	285	WP_000998181.1	hypothetical protein	-
B7437_RS04450	897614..898255	+	642	WP_001019764.1	hypothetical protein	-
B7437_RS04455	898772..899113	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	883316..904064	20748

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T75357 WP_001103942.1 NZ_CP020741:893944-894264 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T75357 NZ_CP020741:893944-894264 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT75357 WP_001058486.1 NZ_CP020741:893732-893941 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT75357 NZ_CP020741:893732-893941 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4