Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 876037..876514 Replicon chromosome
Accession NZ_CP020741
Organism Staphylococcus aureus strain HZW450

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B7437_RS04270 Protein ID WP_000052076.1
Coordinates 876037..876225 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B7437_RS04275 Protein ID WP_001059690.1
Coordinates 876254..876514 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7437_RS04240 872075..872545 + 471 WP_000824462.1 hypothetical protein -
B7437_RS04245 872886..873572 + 687 WP_001823812.1 thermonuclease family protein -
B7437_RS04250 873929..874129 + 201 WP_001059082.1 cold-shock protein -
B7437_RS04255 874628..874846 - 219 WP_000005888.1 hypothetical protein -
B7437_RS04260 874908..875192 - 285 WP_001004397.1 hypothetical protein -
B7437_RS04265 875280..875849 - 570 WP_001106657.1 hypothetical protein -
B7437_RS04270 876037..876225 - 189 WP_000052076.1 hypothetical protein Toxin
B7437_RS04275 876254..876514 - 261 WP_001059690.1 hypothetical protein Antitoxin
B7437_RS04280 876855..877058 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B7437_RS04285 877055..877291 - 237 WP_000368687.1 hypothetical protein -
B7437_RS04290 877516..878097 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
B7437_RS04295 878170..878787 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
B7437_RS04300 878943..879437 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
B7437_RS04305 879836..880258 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
B7437_RS04310 880406..881122 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T75356 WP_000052076.1 NZ_CP020741:c876225-876037 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75356 NZ_CP020741:c876225-876037 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75356 WP_001059690.1 NZ_CP020741:c876514-876254 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75356 NZ_CP020741:c876514-876254 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References