Detailed information of TA system TA075355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3179495..3180014
• Replicon: chromosome
• Accession: NZ_CP020738
• Organism: Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B7P44_RS31850
• Protein ID: WP_084909787.1
• Coordinates: 3179495..3179776 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A102WW84
• Locus tag: B7P44_RS31855
• Protein ID: WP_059610554.1
• Coordinates: 3179766..3180014 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P44_RS31830	3175575..3175888	-	314	Protein_2863	MgtC/SapB family protein	-
B7P44_RS31835	3175999..3177108	+	1110	WP_084909785.1	AGE family epimerase/isomerase	-
B7P44_RS31840	3177081..3178697	-	1617	WP_084909786.1	Tar ligand binding domain-containing protein	-
B7P44_RS31845	3178945..3179388	+	444	WP_017331055.1	PaaI family thioesterase	-
B7P44_RS31850	3179495..3179776	-	282	WP_084909787.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7P44_RS31855	3179766..3180014	-	249	WP_059610554.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
B7P44_RS31860	3180242..3181294	-	1053	WP_084910140.1	CoA transferase	-
B7P44_RS31865	3181427..3182617	-	1191	WP_084909788.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10969.90 Da
• Isoelectric Point: 10.9115

>T75355 WP_084909787.1 NZ_CP020738:c3179776-3179495 [Paraburkholderia acidophila]
MTFELAFLEPALREWKKLDRTVRDQFKSKLAERLEKPRIPSAKLHGHPDRYKIKLRSAGYRLVYEVRDTEVIVLVVAVGR
RERDAVHLAAMKR

Nucleotide

• Length: 282 bp

>T75355 NZ_CP020738:c3179776-3179495 [Paraburkholderia acidophila]
ATGACCTTTGAACTCGCATTTCTCGAACCCGCATTGAGAGAGTGGAAGAAGCTTGATCGCACAGTTCGCGACCAGTTCAA
ATCCAAACTCGCCGAGCGGCTTGAAAAGCCTCGCATACCCTCGGCAAAGCTGCACGGCCACCCGGATCGCTACAAGATCA
AGCTACGCAGCGCCGGCTACCGACTCGTCTACGAAGTGCGCGACACGGAGGTCATCGTGCTGGTTGTCGCAGTCGGTCGG
CGCGAGCGCGATGCAGTCCATCTTGCTGCAATGAAACGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8975.37 Da
• Isoelectric Point: 5.0636

>AT75355 WP_059610554.1 NZ_CP020738:c3180014-3179766 [Paraburkholderia acidophila]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMLERLEDIEDNALADARIKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT75355 NZ_CP020738:c3180014-3179766 [Paraburkholderia acidophila]
ATGCCTCACACGATCCTGGCAAGCGTTACGGCGAGCGTCTCCGAGCTGAAGCGGAACCCGATGGGAACCGTCGCGGCGGG
AGAGGGTTTCCCGGTGGCGATCCTGAACCACAACGAACCGGCGTTCTATTGCATCCCGGCGAAGACTTGGGAGGCGATGC
TCGAACGTCTGGAGGATATCGAAGACAACGCGCTGGCTGATGCGCGTATCAAGGAGAAGGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A102WW84