Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2547593..2548820 Replicon chromosome
Accession NZ_CP020738
Organism Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B7P44_RS28935 Protein ID WP_084909292.1
Coordinates 2548239..2548820 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B7P44_RS28930 Protein ID WP_084909291.1
Coordinates 2547593..2548150 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P44_RS28905 2543279..2543911 + 633 WP_084910085.1 LysE family translocator -
B7P44_RS36810 2544048..2544491 + 444 WP_133117940.1 hypothetical protein -
B7P44_RS28910 2544671..2545009 - 339 Protein_2282 phosphoesterase -
B7P44_RS28915 2545162..2545578 - 417 WP_084909288.1 hypothetical protein -
B7P44_RS28920 2545906..2546637 - 732 WP_084909289.1 ribonuclease T2 -
B7P44_RS28925 2546917..2547561 + 645 WP_084909290.1 hypothetical protein -
B7P44_RS28930 2547593..2548150 + 558 WP_084909291.1 helix-turn-helix domain-containing protein Antitoxin
B7P44_RS28935 2548239..2548820 + 582 WP_084909292.1 HD domain-containing protein Toxin
B7P44_RS28940 2549083..2550276 + 1194 WP_084909293.1 efflux RND transporter periplasmic adaptor subunit -
B7P44_RS28945 2550279..2552315 + 2037 WP_084909294.1 MacB family efflux pump subunit -
B7P44_RS28950 2552328..2553698 + 1371 WP_084909295.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-171)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-61)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21192.82 Da        Isoelectric Point: 5.1032

>T75354 WP_084909292.1 NZ_CP020738:2548239-2548820 [Paraburkholderia acidophila]
MTPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALDGVDPLKLLKLCVVHDLGEALHGDIP
AVEQAAHPDKSAHERRDLLTLTVGLDAALRDEIVSLWDEYEQAASPEAKAVKALDKLETILQHNQGDNPPDFDYAFNLGY
GRRHTDASPLFRAIRAIVDADTQGRIDAGARDA

Download         Length: 582 bp

>T75354 NZ_CP020738:2548239-2548820 [Paraburkholderia acidophila]
ATGACTCCCGACACGATCCACGCCCGGCTCGCCTTCCTGCGCGAAGCGGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCGCGGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGTGTTCGCCGACGCGC
TCGACGGCGTCGACCCGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAAGCGCTGCACGGCGACATCCCG
GCGGTCGAGCAGGCCGCGCACCCGGACAAGAGCGCGCACGAGCGGCGCGACCTGCTGACGCTGACCGTCGGCCTCGACGC
CGCGCTGCGCGACGAGATCGTGTCGCTGTGGGACGAATACGAGCAGGCCGCGTCGCCGGAAGCGAAGGCCGTCAAGGCGC
TGGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGTGACAATCCGCCGGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCCATACGGACGCGAGCCCGCTGTTCCGCGCGATCCGGGCGATCGTCGACGCCGACACGCAAGGCCGGATCGA
CGCCGGCGCGCGGGACGCGTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20224.36 Da        Isoelectric Point: 10.1099

>AT75354 WP_084909291.1 NZ_CP020738:2547593-2548150 [Paraburkholderia acidophila]
MTASPLHTPPLGPLLKRWRLLRRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERAIAERLLAARLDSAGDRALARLVGD
HPGRVHLVCDLTHRLLACSSLRAAEFAKPLPTMLGASLWRYATPEIAALEASLDTLGWRDSAGPPCVEFDSGANASRIVP
IRRSTCRWTRMILSDGSAARLVETL

Download         Length: 558 bp

>AT75354 NZ_CP020738:2547593-2548150 [Paraburkholderia acidophila]
ATGACCGCCTCGCCGCTTCACACTCCGCCGCTCGGCCCGCTGCTGAAACGCTGGCGGCTCCTGCGCCGCGTGAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATTTCCCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGATCGCCGAGCGCCTGCTCGCGGCGCGGCTCGATTCCGCCGGCGACCGCGCGCTCGCGCGGCTCGTCGGCGAC
CATCCCGGCCGCGTGCACCTCGTGTGCGACCTCACGCACCGGCTGCTGGCATGCTCGTCGCTGCGCGCCGCCGAATTCGC
GAAACCGCTGCCGACGATGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCGCGCTGGAGGCGTCGCTCG
ACACGCTCGGCTGGCGCGACAGCGCCGGCCCGCCGTGCGTCGAGTTCGACAGCGGCGCGAACGCGTCGCGCATCGTGCCG
ATCCGCCGCAGCACCTGCCGCTGGACCCGGATGATCCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References