Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2366698..2367353 Replicon chromosome
Accession NZ_CP020738
Organism Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B7P44_RS28065 Protein ID WP_084909143.1
Coordinates 2366698..2367117 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B7P44_RS28070 Protein ID WP_084909144.1
Coordinates 2367114..2367353 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P44_RS28035 2361846..2362646 + 801 WP_084909139.1 AraC family transcriptional regulator -
B7P44_RS28040 2362733..2363656 + 924 WP_084910066.1 DMT family transporter -
B7P44_RS28045 2363846..2364418 + 573 WP_084909140.1 permease -
B7P44_RS28050 2364518..2364652 - 135 WP_021158165.1 entericidin A/B family lipoprotein -
B7P44_RS28055 2364884..2366179 + 1296 WP_084909141.1 aspartate carbamoyltransferase -
B7P44_RS28060 2366315..2366632 + 318 WP_084909142.1 hypothetical protein -
B7P44_RS28065 2366698..2367117 - 420 WP_084909143.1 type II toxin-antitoxin system VapC family toxin Toxin
B7P44_RS28070 2367114..2367353 - 240 WP_084909144.1 Arc family DNA-binding protein Antitoxin
B7P44_RS28075 2367662..2369899 + 2238 WP_084909145.1 TonB-dependent siderophore receptor -
B7P44_RS28080 2369903..2370658 + 756 WP_084909146.1 sel1 repeat family protein -
B7P44_RS28085 2370655..2371338 + 684 WP_084909147.1 Fe2+-dependent dioxygenase -
B7P44_RS28090 2371411..2372181 - 771 WP_084909148.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15008.27 Da        Isoelectric Point: 5.8883

>T75353 WP_084909143.1 NZ_CP020738:c2367117-2366698 [Paraburkholderia acidophila]
MILVDTNVISEPLRPAPNASVLEWLDAQNVETLFLAAISLAEMRFGVAAMPEGKRRDWLHRSIEQRVVPVFRGRILPFDT
AASEAYARLRARARAAGSAIAPADGYIAATAEANGLIVATRDIAPFEAAGLRAIDPWAV

Download         Length: 420 bp

>T75353 NZ_CP020738:c2367117-2366698 [Paraburkholderia acidophila]
ATGATTCTTGTCGATACCAACGTCATATCCGAGCCGCTTCGGCCTGCGCCGAATGCGTCAGTGCTGGAGTGGCTCGACGC
CCAGAATGTCGAAACCTTGTTTCTGGCGGCGATCAGTCTGGCCGAGATGAGATTCGGCGTCGCCGCGATGCCTGAAGGCA
AGCGGCGAGACTGGCTGCATCGAAGCATTGAACAAAGAGTGGTGCCGGTATTCCGCGGCCGGATTTTGCCGTTCGACACG
GCTGCGAGCGAGGCCTATGCCAGGCTTCGCGCACGCGCGCGGGCGGCCGGCAGCGCGATCGCGCCTGCCGATGGCTATAT
CGCCGCGACCGCCGAAGCGAACGGATTGATCGTGGCGACGCGCGACATCGCGCCATTCGAGGCGGCTGGCCTGAGGGCGA
TCGATCCGTGGGCGGTCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8838.12 Da        Isoelectric Point: 5.1585

>AT75353 WP_084909144.1 NZ_CP020738:c2367353-2367114 [Paraburkholderia acidophila]
MPVITVRNLPDEVHRALRIRAAEHGRSTEAEVRDILEKAVQPEGRLKLGTLLAEIGREIGGVDLDIPRDKTPTEPMNFE

Download         Length: 240 bp

>AT75353 NZ_CP020738:c2367353-2367114 [Paraburkholderia acidophila]
ATGCCAGTGATAACCGTTCGGAACTTGCCTGACGAAGTCCATCGCGCGCTTCGGATTCGCGCGGCGGAGCATGGACGCAG
CACCGAAGCGGAGGTGCGTGACATCCTCGAGAAAGCGGTCCAGCCGGAAGGGCGTCTCAAATTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAAATCGGGGGTGTCGATCTCGACATTCCGCGCGACAAAACCCCAACCGAGCCGATGAACTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References