Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2171719..2173493 Replicon chromosome
Accession NZ_CP020738
Organism Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag B7P44_RS27085 Protein ID WP_084908985.1
Coordinates 2172567..2173493 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag B7P44_RS27080 Protein ID WP_084908984.1
Coordinates 2171719..2172570 (-) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P44_RS27060 2166825..2168315 - 1491 WP_084908980.1 aldehyde dehydrogenase -
B7P44_RS27065 2168442..2169269 - 828 WP_084908981.1 aspartate dehydrogenase -
B7P44_RS27070 2169262..2170929 - 1668 WP_084908982.1 thiamine pyrophosphate-binding protein -
B7P44_RS27075 2170922..2171719 - 798 WP_084908983.1 SDR family oxidoreductase -
B7P44_RS27080 2171719..2172570 - 852 WP_084908984.1 IclR family transcriptional regulator Antitoxin
B7P44_RS27085 2172567..2173493 - 927 WP_084908985.1 alpha/beta fold hydrolase Toxin
B7P44_RS27090 2173512..2174039 - 528 WP_084910045.1 cupin domain-containing protein -
B7P44_RS27095 2174066..2174836 - 771 WP_084908986.1 SDR family oxidoreductase -
B7P44_RS27100 2174829..2175899 - 1071 WP_084908987.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
B7P44_RS27105 2175943..2176254 - 312 WP_084908988.1 hypothetical protein -
B7P44_RS27110 2176256..2176573 - 318 WP_060256840.1 non-heme iron oxygenase ferredoxin subunit -
B7P44_RS27115 2177009..2178088 + 1080 WP_084908989.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(61-289)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 31552.95 Da        Isoelectric Point: 8.9880

>T75352 WP_084908985.1 NZ_CP020738:c2173493-2172567 [Paraburkholderia acidophila]
MSVIDKRARERIASFAALLERFPEQRCAAGAAGTIGYRAAGAQHADRTLAGRTLAGRAHPVVLLHGIGSGAASWVRQLDA
LGASRRVFAWDAPGYGASTPVRGASPAAADYAASLGAWLDALGVDRCVLVGHSLGAIVAGGFARVMPERVAGLLLISPAG
GYGSAPAETRASRRDARLAMLDELGPAGLAAQRSGNMLSGNACEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAG
FRGRAAVAVGANDAITPPAACERIAAAAHVGLQVIPQVGHAGYVEAPAVYSALIDGFCRQCDAQRGMA

Download         Length: 927 bp

>T75352 NZ_CP020738:c2173493-2172567 [Paraburkholderia acidophila]
ATGAGTGTCATCGACAAACGTGCGCGCGAGCGCATCGCGAGCTTCGCGGCGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCGGCCGGCGCGGCCGGCACGATCGGCTATCGCGCGGCCGGCGCGCAGCATGCGGATCGCACCTTGGCCGGTCGCACCT
TGGCCGGCCGCGCGCACCCCGTCGTGCTGCTGCACGGCATCGGCTCGGGCGCCGCGTCGTGGGTGCGTCAGCTCGATGCG
CTCGGCGCCTCGCGGCGCGTGTTCGCCTGGGACGCACCCGGCTACGGTGCGTCGACGCCGGTGCGCGGCGCATCGCCGGC
CGCCGCCGACTACGCGGCGTCGCTCGGCGCGTGGCTCGATGCGCTCGGCGTCGACCGCTGCGTGCTGGTCGGCCATTCGC
TCGGCGCGATCGTCGCGGGCGGCTTCGCCCGCGTGATGCCGGAGCGCGTCGCCGGGCTGCTGCTGATCTCGCCCGCGGGC
GGCTACGGCAGCGCGCCGGCCGAGACGCGCGCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGACGAACTCGGCCCCGC
CGGGCTCGCCGCGCAGCGCAGCGGCAACATGCTGTCCGGCAACGCGTGCGAGGACGCGCGCGCCTGGGTGCGCTGGAACA
TGGCGCGCATCGTGCCGGCCGGCTACGCGCAGGCGACGCATCTGCTCGCGAACGCCGATCTCGCATCCGACCTCGCGGGC
TTTCGCGGCCGCGCGGCGGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGC
CGCACACGTCGGGCTGCAGGTGATTCCGCAGGTCGGGCATGCGGGTTACGTGGAAGCGCCGGCCGTCTATTCCGCGCTGA
TCGACGGGTTCTGCCGTCAGTGCGACGCGCAGCGGGGGATGGCATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 30945.44 Da        Isoelectric Point: 6.3568

>AT75352 WP_084908984.1 NZ_CP020738:c2172570-2171719 [Paraburkholderia acidophila]
MSEPLLNETEGAKGEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLGELRALYPEGALQRMTQATPDTVDALYSVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDAVLIADGLVDKVQRAAAELSRRLNYRSDDEHTFLKALGL

Download         Length: 852 bp

>AT75352 NZ_CP020738:c2172570-2171719 [Paraburkholderia acidophila]
ATGAGCGAACCGCTGTTGAACGAAACCGAAGGCGCGAAGGGCGAAGCGAACTACGTGGTGCCGGGCCTCGAGCGGGGCTT
GAGGATTCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCGGTGATCGAAAG
CCTGCGCGACGCAACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGCCGGTGTTCAGCTCGATCCGGGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACCACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGGGCGAGCTGCGCGCGCTGTATCCGGAAGGCGCGCTGCAGCGGATGACGCAGGCGACGCC
GGACACGGTCGACGCGCTGTACAGCGTGATCCGCGAGGACGCGTTGCGCGGCTACGGCGTCAGCAACTCGTCGTTCGAGC
GCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGGTGCTGATCGCGGACGGCCTGGTCGACAAGGTGCAGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAACTACCGCTCGGACGACGAGCATACGTTTCTGAAGGCTTTGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References