Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1800115..1800791 Replicon chromosome
Accession NZ_CP020737
Organism Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag B7P44_RS08530 Protein ID WP_084902822.1
Coordinates 1800375..1800791 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag B7P44_RS08525 Protein ID WP_084902819.1
Coordinates 1800115..1800378 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P44_RS08510 1795668..1797890 + 2223 WP_084902810.1 TonB-dependent siderophore receptor -
B7P44_RS08515 1797961..1798809 + 849 WP_084902813.1 N(5)-hydroxyornithine transformylase PvdF -
B7P44_RS08520 1798809..1799855 + 1047 WP_084902816.1 acetyltransferase -
B7P44_RS08525 1800115..1800378 + 264 WP_084902819.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B7P44_RS08530 1800375..1800791 + 417 WP_084902822.1 PIN domain-containing protein Toxin
B7P44_RS08535 1800955..1802118 + 1164 WP_084902825.1 amidohydrolase -
B7P44_RS08540 1802325..1802864 + 540 WP_084902827.1 outer membrane protein assembly factor BamE -
B7P44_RS08545 1803006..1804307 - 1302 WP_084902829.1 cobyrinate a,c-diamide synthase -
B7P44_RS08550 1804311..1804913 - 603 WP_010092402.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
B7P44_RS08555 1804942..1805316 - 375 WP_084902831.1 cobalamin biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14721.84 Da        Isoelectric Point: 7.3224

>T75349 WP_084902822.1 NZ_CP020737:1800375-1800791 [Paraburkholderia acidophila]
VTKLYMLDTNICSYIMRERPPVVLSRLQSCVGAQHRIVVSAVTYAEMRFGTIGRKASPKHADLVTAFVARLDGVLPWDAA
AVDATTAVRAELAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVDGLSFEDWAD

Download         Length: 417 bp

>T75349 NZ_CP020737:1800375-1800791 [Paraburkholderia acidophila]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGTTCATACATCATGCGGGAGCGGCCGCCGGTCGTCCTGTCGCGGCT
GCAGTCGTGCGTCGGCGCCCAGCACCGGATCGTCGTGTCGGCCGTCACCTATGCGGAGATGCGCTTCGGCACGATCGGCC
GGAAGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCGCGCGGCTGGACGGCGTGCTGCCGTGGGATGCGGCG
GCCGTCGACGCGACCACCGCCGTGCGCGCCGAGCTTGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGCGCGGTGCTGGTGACCCACAATACGCGCGAATTCGGCCGCGTCGACGGGTTGTCGTTCG
AGGATTGGGCGGACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9780.97 Da        Isoelectric Point: 4.4179

>AT75349 WP_084902819.1 NZ_CP020737:1800115-1800378 [Paraburkholderia acidophila]
MRTVSIFKNASNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVVESGRFDLSGPDD
EPTESGR

Download         Length: 264 bp

>AT75349 NZ_CP020737:1800115-1800378 [Paraburkholderia acidophila]
ATGCGCACCGTTTCCATTTTCAAGAATGCCAGCAATCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGATACGCTGCTGCTTCGGCCCGTGCGCCCCACGTGGACGTCGCTCGCGCATGAAC
CGCTTGCGGATGCCGATTTCCTCGTCGAGCGCCCGGCCGTCGTCGAATCCGGCCGTTTCGACCTGTCCGGCCCGGACGAT
GAGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References