Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 11204..11876 Replicon chromosome
Accession NZ_CP020715
Organism Cnuibacter physcomitrellae strain XA(T)

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B5808_RS00055 Protein ID WP_085017615.1
Coordinates 11204..11599 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B5808_RS00060 Protein ID WP_085017616.1
Coordinates 11601..11876 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5808_RS00035 7899..10376 + 2478 WP_115364892.1 DNA gyrase subunit A -
B5808_RS00040 10369..10776 + 408 WP_085017614.1 DUF3566 domain-containing protein -
B5808_RS00055 11204..11599 - 396 WP_085017615.1 type II toxin-antitoxin system VapC family toxin Toxin
B5808_RS00060 11601..11876 - 276 WP_085017616.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B5808_RS00065 11962..12528 - 567 WP_085017617.1 hypothetical protein -
B5808_RS00070 12669..13208 + 540 WP_085017618.1 peptidylprolyl isomerase -
B5808_RS00075 13237..14118 + 882 WP_085017619.1 rhomboid family intramembrane serine protease -
B5808_RS00080 14191..14457 - 267 WP_085017620.1 cell division protein CrgA -
B5808_RS00085 14558..15385 + 828 WP_174604345.1 class E sortase -
B5808_RS21065 15385..15546 + 162 WP_162818385.1 DUF4175 domain-containing protein -
B5808_RS00090 15543..16181 + 639 WP_085017621.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-48)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14210.12 Da        Isoelectric Point: 5.9708

>T75342 WP_085017615.1 NZ_CP020715:c11599-11204 [Cnuibacter physcomitrellae]
VYSYFDSSAFVKLVIPEEASVELKAWVDGSSLSPISNDLLHTEILRAVRRRAPQRLPDARHLLSGVLTASITTSIADRAA
WLEPPSVRSLDALHVATALEIGDGVHAFVTYDTRMQECARAHGFDVVAPGA

Download         Length: 396 bp

>T75342 NZ_CP020715:c11599-11204 [Cnuibacter physcomitrellae]
GTGTACTCCTACTTCGACTCGTCCGCGTTCGTGAAGCTGGTCATTCCCGAGGAGGCCAGTGTGGAGTTGAAAGCGTGGGT
CGATGGATCTTCGCTCAGCCCCATCTCCAATGATCTCCTTCACACCGAGATCCTGCGCGCAGTCAGACGGCGTGCCCCTC
AGCGCCTTCCTGACGCGCGCCACCTGCTCTCCGGTGTGCTGACGGCGTCCATCACGACGAGCATCGCCGACAGGGCCGCG
TGGCTCGAGCCACCGTCGGTCCGATCGCTCGACGCGCTCCACGTCGCGACAGCCCTGGAGATCGGCGATGGAGTCCACGC
CTTCGTCACGTACGACACCCGGATGCAGGAATGCGCCAGGGCACATGGGTTCGATGTGGTGGCGCCGGGGGCGTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9851.28 Da        Isoelectric Point: 4.7872

>AT75342 WP_085017616.1 NZ_CP020715:c11876-11601 [Cnuibacter physcomitrellae]
MAEVGIRALKQNASAVVARVAAGETVTITDRGRPVALMTPIRPSRVEEMIASGQIRPATRSLADMPLPKPLDDDGPTLSE
VLQQMRDEDDR

Download         Length: 276 bp

>AT75342 NZ_CP020715:c11876-11601 [Cnuibacter physcomitrellae]
ATGGCCGAGGTCGGGATTCGGGCGCTGAAGCAGAACGCTTCCGCCGTCGTCGCACGAGTAGCCGCAGGTGAGACAGTGAC
CATCACCGACAGAGGGCGCCCCGTCGCGCTCATGACCCCGATACGCCCGTCGCGCGTCGAGGAGATGATCGCGTCGGGCC
AGATCAGGCCCGCCACACGATCGTTGGCCGACATGCCGCTCCCGAAGCCCCTCGACGACGACGGCCCCACGTTGTCGGAG
GTGCTGCAGCAGATGCGCGACGAAGACGACCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References