Detailed information of TA system TA075337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2520502..2521034
• Replicon: chromosome
• Accession: NZ_CP020714
• Organism: Staphylococcus aureus strain K18

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: B7474_RS13175
• Protein ID: WP_001103944.1
• Coordinates: 2520502..2520822 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: B7474_RS13180
• Protein ID: WP_001058486.1
• Coordinates: 2520825..2521034 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7474_RS13155	2516504..2517145	-	642	WP_101766726.1	pathogenicity island protein	-
B7474_RS13160	2517142..2517522	-	381	WP_020977426.1	hypothetical protein	-
B7474_RS13165	2517852..2519552	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
B7474_RS13170	2519566..2520435	-	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
B7474_RS13175	2520502..2520822	-	321	WP_001103944.1	DUF1474 family protein	Toxin
B7474_RS13180	2520825..2521034	-	210	WP_001058486.1	hypothetical protein	Antitoxin
B7474_RS13185	2521027..2521173	-	147	WP_000708434.1	hypothetical protein	-
B7474_RS13190	2521170..2521487	-	318	WP_069724350.1	helix-turn-helix domain-containing protein	-
B7474_RS13195	2521492..2521710	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
B7474_RS13200	2521883..2522557	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
B7474_RS13205	2522571..2523743	+	1173	WP_000179346.1	site-specific integrase	-
B7474_RS13210	2523812..2525428	-	1617	WP_000240642.1	chaperonin GroEL	-
B7474_RS13215	2525504..2525788	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2516081..2525788	9707

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T75337 WP_001103944.1 NZ_CP020714:c2520822-2520502 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T75337 NZ_CP020714:c2520822-2520502 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT75337 WP_001058486.1 NZ_CP020714:c2521034-2520825 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT75337 NZ_CP020714:c2521034-2520825 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9