Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2244952..2245466 Replicon chromosome
Accession NZ_CP020714
Organism Staphylococcus aureus strain K18

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag B7474_RS11710 Protein ID WP_000581793.1
Coordinates 2244952..2245161 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag B7474_RS11715 Protein ID WP_000138932.1
Coordinates 2245173..2245466 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7474_RS11690 2240461..2241819 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
B7474_RS11695 2241834..2242904 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
B7474_RS11700 2243222..2244424 + 1203 WP_001109939.1 rod shape-determining protein RodA -
B7474_RS11705 2244687..2244824 - 138 WP_000828354.1 hypothetical protein -
B7474_RS11710 2244952..2245161 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
B7474_RS11715 2245173..2245466 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
B7474_RS11720 2245632..2247116 + 1485 WP_000571549.1 cardiolipin synthase -
B7474_RS11725 2247144..2247791 + 648 WP_001187628.1 HD domain-containing protein -
B7474_RS11740 2248405..2249277 - 873 WP_000725802.1 membrane protein insertase YidC -
B7474_RS11745 2249363..2250004 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T75335 WP_000581793.1 NZ_CP020714:c2245161-2244952 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T75335 NZ_CP020714:c2245161-2244952 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT75335 WP_000138932.1 NZ_CP020714:c2245466-2245173 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT75335 NZ_CP020714:c2245466-2245173 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References