Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 933935..934412 Replicon chromosome
Accession NZ_CP020714
Organism Staphylococcus aureus strain K18

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B7474_RS04750 Protein ID WP_000052076.1
Coordinates 934224..934412 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B7474_RS04745 Protein ID WP_001059690.1
Coordinates 933935..934195 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7474_RS04710 929332..930048 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
B7474_RS04715 930196..930618 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
B7474_RS04720 931013..931495 + 483 WP_101766680.1 GNAT family N-acetyltransferase -
B7474_RS04725 931662..932279 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
B7474_RS04730 932403..932933 - 531 WP_173677721.1 phosphoglycerate mutase family protein -
B7474_RS04735 933158..933394 + 237 WP_000368687.1 hypothetical protein -
B7474_RS04740 933391..933594 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B7474_RS04745 933935..934195 + 261 WP_001059690.1 hypothetical protein Antitoxin
B7474_RS04750 934224..934412 + 189 WP_000052076.1 hypothetical protein Toxin
B7474_RS04755 934600..935169 + 570 WP_001106652.1 hypothetical protein -
B7474_RS04760 935257..935541 + 285 WP_001004401.1 hypothetical protein -
B7474_RS04765 935603..935821 + 219 WP_000005887.1 hypothetical protein -
B7474_RS04770 936317..936517 - 201 WP_001059082.1 cold-shock protein -
B7474_RS04775 936874..937560 - 687 WP_001641381.1 thermonuclease family protein -
B7474_RS04780 937901..938377 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T75327 WP_000052076.1 NZ_CP020714:934224-934412 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75327 NZ_CP020714:934224-934412 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75327 WP_001059690.1 NZ_CP020714:933935-934195 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75327 NZ_CP020714:933935-934195 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References