Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2200217..2200731 Replicon chromosome
Accession NZ_CP020713
Organism Staphylococcus aureus strain K17

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag B7473_RS11365 Protein ID WP_000581793.1
Coordinates 2200522..2200731 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag B7473_RS11360 Protein ID WP_000138932.1
Coordinates 2200217..2200510 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7473_RS11330 2195679..2196320 + 642 WP_000483155.1 thiamine phosphate synthase -
B7473_RS11335 2196406..2197278 + 873 WP_000725802.1 membrane protein insertase YidC -
B7473_RS11350 2197892..2198539 - 648 WP_001187628.1 HD domain-containing protein -
B7473_RS11355 2198567..2200051 - 1485 WP_000571549.1 cardiolipin synthase -
B7473_RS11360 2200217..2200510 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
B7473_RS11365 2200522..2200731 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
B7473_RS11370 2200859..2200996 + 138 WP_000828354.1 hypothetical protein -
B7473_RS11375 2201259..2202461 - 1203 WP_001109939.1 rod shape-determining protein RodA -
B7473_RS11380 2202779..2203849 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
B7473_RS11385 2203864..2205222 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T75321 WP_000581793.1 NZ_CP020713:2200522-2200731 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T75321 NZ_CP020713:2200522-2200731 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT75321 WP_000138932.1 NZ_CP020713:2200217-2200510 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT75321 NZ_CP020713:2200217-2200510 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References