Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2081011..2081488 Replicon chromosome
Accession NZ_CP020713
Organism Staphylococcus aureus strain K17

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B7473_RS10675 Protein ID WP_000052076.1
Coordinates 2081011..2081199 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B7473_RS10680 Protein ID WP_001059690.1
Coordinates 2081228..2081488 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7473_RS10645 2077046..2077522 + 477 WP_000824477.1 hypothetical protein -
B7473_RS10650 2077863..2078549 + 687 WP_001641381.1 thermonuclease family protein -
B7473_RS10655 2078906..2079106 + 201 WP_001059082.1 cold-shock protein -
B7473_RS10660 2079602..2079820 - 219 WP_000005887.1 hypothetical protein -
B7473_RS10665 2079882..2080166 - 285 WP_001004401.1 hypothetical protein -
B7473_RS10670 2080254..2080823 - 570 WP_001106652.1 hypothetical protein -
B7473_RS10675 2081011..2081199 - 189 WP_000052076.1 hypothetical protein Toxin
B7473_RS10680 2081228..2081488 - 261 WP_001059690.1 hypothetical protein Antitoxin
B7473_RS10685 2081829..2082032 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B7473_RS10690 2082029..2082265 - 237 WP_000368687.1 hypothetical protein -
B7473_RS10695 2082490..2083020 + 531 WP_173677721.1 phosphoglycerate mutase family protein -
B7473_RS10700 2083144..2083761 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
B7473_RS10705 2083928..2084410 - 483 WP_101766680.1 GNAT family N-acetyltransferase -
B7473_RS10710 2084806..2085228 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B7473_RS10715 2085376..2086092 + 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 2019750..2084410 64660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T75320 WP_000052076.1 NZ_CP020713:c2081199-2081011 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75320 NZ_CP020713:c2081199-2081011 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75320 WP_001059690.1 NZ_CP020713:c2081488-2081228 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75320 NZ_CP020713:c2081488-2081228 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References