Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5044157..5044704 Replicon chromosome
Accession NZ_CP020704
Organism Pseudomonas aeruginosa strain PASGNDM699

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag B7W87_RS24480 Protein ID WP_085286979.1
Coordinates 5044157..5044432 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag B7W87_RS24485 Protein ID WP_085286980.1
Coordinates 5044432..5044704 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7W87_RS24455 5039621..5041120 + 1500 WP_033988138.1 amidase -
B7W87_RS24460 5041221..5041568 + 348 WP_049251069.1 DUF2834 domain-containing protein -
B7W87_RS24465 5041790..5043037 + 1248 WP_085286977.1 TonB-dependent receptor -
B7W87_RS24470 5043151..5043768 + 618 WP_034075648.1 response regulator transcription factor -
B7W87_RS24475 5043818..5044057 - 240 WP_157131547.1 hypothetical protein -
B7W87_RS24480 5044157..5044432 - 276 WP_085286979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7W87_RS24485 5044432..5044704 - 273 WP_085286980.1 ribbon-helix-helix domain-containing protein Antitoxin
B7W87_RS24490 5044726..5045463 - 738 WP_085286981.1 DUF2807 domain-containing protein -
B7W87_RS24495 5045749..5046309 + 561 WP_003117272.1 recombinase family protein -
B7W87_RS24500 5046313..5049279 + 2967 WP_003117273.1 Tn3-like element ISPa40 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4986378..5078349 91971
- flank IS/Tn - - 5038183..5039484 1301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10795.34 Da        Isoelectric Point: 7.0128

>T75310 WP_085286979.1 NZ_CP020704:c5044432-5044157 [Pseudomonas aeruginosa]
MELKWTSKALSDITRLYEFLATVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFEPRDVRRIQIGQYEMRYEIVDSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T75310 NZ_CP020704:c5044432-5044157 [Pseudomonas aeruginosa]
ATGGAATTGAAGTGGACAAGCAAGGCGCTTTCCGACATTACCCGACTGTACGAGTTTCTTGCCACGGTGAATCAGCCTGC
CGCCGCACGAACAGTGCAGCAACTCACAGCCGCACCTACCACGCTGCTGACCAACCCGCGCATTGGCGAACGGCTGGAAG
AGTTCGAGCCAAGGGATGTACGCCGAATTCAGATCGGCCAATACGAGATGCGTTACGAGATAGTGGATTCCACTATCTAC
CTGCTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10091.37 Da        Isoelectric Point: 5.6994

>AT75310 WP_085286980.1 NZ_CP020704:c5044704-5044432 [Pseudomonas aeruginosa]
MATTAKTRSVTAHVPEQLAQKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
SSDTPLPVPR

Download         Length: 273 bp

>AT75310 NZ_CP020704:c5044704-5044432 [Pseudomonas aeruginosa]
ATGGCAACCACCGCGAAAACCCGATCTGTCACGGCTCACGTCCCTGAGCAACTGGCCCAAAAGGTCGATTTGATGGCAGA
GCGTCTGGAGCGCTCCAAAAACTGGATCGTCAAACAGGCTCTGTCCGCTTGGATAGATCAGGAAGAAGAGCGTAGCCGCC
TGACCCGTGAGGCCTTAGCCGATGTTGACGCTGGCCGCGTTATTGACCACCAAGCCGTCCAGGCCTGGGCTGACAGCCTC
AGCTCCGACACTCCGTTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References