Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4885130..4885782 Replicon chromosome
Accession NZ_CP020704
Organism Pseudomonas aeruginosa strain PASGNDM699

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B7W87_RS23605 Protein ID WP_003134109.1
Coordinates 4885130..4885540 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B7W87_RS23610 Protein ID WP_170869361.1
Coordinates 4885540..4885782 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7W87_RS33945 4881412..4881825 - 414 WP_153570846.1 hypothetical protein -
B7W87_RS23565 4881836..4881976 + 141 WP_153549538.1 hypothetical protein -
B7W87_RS23570 4882133..4882861 + 729 WP_023094843.1 TIGR03761 family integrating conjugative element protein -
B7W87_RS23575 4882867..4883400 + 534 WP_003134105.1 DUF3158 family protein -
B7W87_RS23580 4883414..4883902 + 489 WP_003134107.1 single-stranded DNA-binding protein -
B7W87_RS23585 4884006..4884200 + 195 WP_031632157.1 hypothetical protein -
B7W87_RS23590 4884452..4884619 + 168 WP_128729268.1 CrpP family protein -
B7W87_RS23595 4884685..4884903 - 219 WP_023094844.1 hypothetical protein -
B7W87_RS23600 4884920..4885114 - 195 WP_023094845.1 hypothetical protein -
B7W87_RS23605 4885130..4885540 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
B7W87_RS23610 4885540..4885782 - 243 WP_170869361.1 antitoxin Antitoxin
B7W87_RS23615 4886088..4888007 + 1920 WP_003134111.1 type I DNA topoisomerase -
B7W87_RS23620 4888015..4888767 + 753 Protein_4561 hypothetical protein -
B7W87_RS23625 4888884..4889489 - 606 WP_023094848.1 LysE family translocator -
B7W87_RS23630 4889611..4890480 + 870 WP_023094849.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T75309 WP_003134109.1 NZ_CP020704:c4885540-4885130 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T75309 NZ_CP020704:c4885540-4885130 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGTCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGTCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8909.94 Da        Isoelectric Point: 4.4230

>AT75309 WP_170869361.1 NZ_CP020704:c4885782-4885540 [Pseudomonas aeruginosa]
MRCVVEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 243 bp

>AT75309 NZ_CP020704:c4885782-4885540 [Pseudomonas aeruginosa]
ATGAGGTGTGTCGTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCT
TCCTGATGACGTTAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGTGAGTCTTGGGATA
GCTGGTTCGATGGCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References