75294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5317566..5318091 Replicon chromosome
Accession NZ_CP020700
Organism Streptomyces tsukubensis strain NRRL 18488

Toxin (Protein)


Gene name relE Uniprot ID I2N5J6
Locus tag B7R87_RS22080 Protein ID WP_006346847.1
Coordinates 5317566..5317829 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G3UBC1
Locus tag B7R87_RS22085 Protein ID WP_030744248.1
Coordinates 5317822..5318091 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R87_RS22060 5313528..5314532 + 1005 WP_040914471.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
B7R87_RS22065 5314563..5315318 + 756 WP_040914468.1 ROK family protein -
B7R87_RS22070 5315364..5315963 - 600 WP_006346849.1 hypothetical protein -
B7R87_RS22075 5316343..5317431 + 1089 WP_006346848.1 redox-regulated ATPase YchF -
B7R87_RS22080 5317566..5317829 - 264 WP_006346847.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7R87_RS22085 5317822..5318091 - 270 WP_030744248.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B7R87_RS22090 5318181..5318531 - 351 WP_006346845.1 DUF4326 domain-containing protein -
B7R87_RS22095 5318772..5320217 + 1446 WP_130584856.1 DUF4190 domain-containing protein -
B7R87_RS22100 5320596..5321939 - 1344 WP_040914462.1 glycoside hydrolase family 18 protein -
B7R87_RS22105 5322234..5322986 + 753 WP_006346841.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10040.52 Da        Isoelectric Point: 7.1641

>T75294 WP_006346847.1 NZ_CP020700:c5317829-5317566 [Streptomyces tsukubensis]
VSEYRTVFCPEAQAELRKIPRDMALRILAKLTELEADPLGFSTTALVSQPDRRRLRMGDYRVVYTIDNGELVVWFVHVGH
RSTVYDT

Download         Length: 264 bp

>T75294 NZ_CP020700:c5317829-5317566 [Streptomyces tsukubensis]
GTGAGTGAGTACCGAACCGTCTTCTGCCCCGAAGCGCAGGCCGAACTCCGGAAGATCCCCCGCGATATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAACTGGAGGCCGATCCACTCGGCTTCAGCACCACCGCGCTCGTGTCCCAGCCGGACCGCCGAC
GCCTGCGGATGGGCGACTACCGCGTCGTCTACACGATCGACAATGGAGAGTTGGTGGTTTGGTTCGTTCATGTGGGACAT
CGGTCCACCGTCTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10258.73 Da        Isoelectric Point: 4.7473

>AT75294 WP_030744248.1 NZ_CP020700:c5318091-5317822 [Streptomyces tsukubensis]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT75294 NZ_CP020700:c5318091-5317822 [Streptomyces tsukubensis]
ATGACACAGCCGCTGCCCATAGAGTCCATCCGTGACGTGCGTGCACATTTGGCGGAGGTCGTGGAGCGCGCGGACCGGGA
CGATGTGCCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCTCCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCCCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2N5J6

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3UBC1

References