Detailed information of TA system TA075290

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 11322..11883
• Replicon: plasmid p2SUD7
• Accession: NZ_CP020696
• Organism: Sulfitobacter sp. D7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AH87
• Locus tag: B5M07_RS17475
• Protein ID: WP_071974127.1
• Coordinates: 11608..11883 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: B5M07_RS17470
• Protein ID: WP_044353023.1
• Coordinates: 11322..11621 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5M07_RS17445	6805..7206	-	402	WP_120352465.1	L-alanine exporter AlaE	-
B5M07_RS17450	7366..7755	+	390	WP_120352466.1	DUF3768 domain-containing protein	-
B5M07_RS17455	7911..9893	+	1983	WP_120352467.1	ParB/RepB/Spo0J family partition protein	-
B5M07_RS17460	9968..10561	+	594	WP_120352468.1	regulator	-
B5M07_RS17465	10561..11217	+	657	WP_120352469.1	hypothetical protein	-
B5M07_RS17470	11322..11621	+	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B5M07_RS17475	11608..11883	+	276	WP_071974127.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
B5M07_RS17480	11990..15058	+	3069	Protein_13	strawberry notch family protein	-
B5M07_RS17485	15089..16360	-	1272	WP_120350436.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..126656	126656
	-	flank	IS/Tn	-	-	15089..16360	1271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10388.92 Da
• Isoelectric Point: 4.5837

>T75290 WP_071974127.1 NZ_CP020696:11608-11883 [Sulfitobacter sp. D7]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T75290 NZ_CP020696:11608-11883 [Sulfitobacter sp. D7]
TTGCCAAATCTTGAATGGAAAGCCACGGCCATCGCCGACTTGTTGGCAATCATTGACTACATCTCTGACGACAACCCGGA
TGCCGCCCAAGTTCTCAAAGACGAGATTGAACACAAGACGTCCCTCCTTCCAGAACGCCCTCAGATGTACCGCGCGGGCC
GTGTGGACGGGACTAGGGAGATGGTTGTTCGGCCAAACTACATCGTGGTTTATGCTGAAAGCCCTGAGATGGTGACCATT
TTGCGCGTACTTCATGCTGCGCAGCAGTGGCCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT75290 WP_044353023.1 NZ_CP020696:11322-11621 [Sulfitobacter sp. D7]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT75290 NZ_CP020696:11322-11621 [Sulfitobacter sp. D7]
ATGCCTGCCCAAACATCCATGCTTCATGTTCGTGTTGACGATCAGCTGAAAGCACAGGCTTCGGACGCACTTGCGGGCGT
CGGTCTGACGCTCTCCGATGCGGTGCGTATTCTTCTGACCCGCGTGGCCGCAGAAGGCGGATTGCCTGCCGGATTGACCG
CTGATCCGGATGCCTATGATGCCTGGTTCCGGGCGAAGGTACAGGAAGCGCTGGACGATCCAAGGCCCACAACGCCCCAT
GCCAAGGCGATGCAAGACGCCCAGGCATTGATTGACGGGAAGCGCCTTGCCAAATCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2