Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 4661603..4662036 Replicon chromosome
Accession NZ_CP020664
Organism Microcystis sp. MC19

Toxin (Protein)


Gene name hicA Uniprot ID L7ED23
Locus tag B5D77_RS23760 Protein ID WP_002733933.1
Coordinates 4661812..4662036 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID I4IBE8
Locus tag B5D77_RS23755 Protein ID WP_008199545.1
Coordinates 4661603..4661815 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5D77_RS23730 4657086..4659257 - 2172 WP_106909774.1 glutamine synthetase III -
B5D77_RS23740 4659755..4660612 + 858 WP_106910060.1 PEP-CTERM sorting domain-containing protein -
B5D77_RS23745 4660669..4660941 - 273 Protein_4416 Txe/YoeB family addiction module toxin -
B5D77_RS23750 4660925..4661224 - 300 WP_002763657.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B5D77_RS23755 4661603..4661815 + 213 WP_008199545.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B5D77_RS23760 4661812..4662036 + 225 WP_002733933.1 type II toxin-antitoxin system HicA family toxin Toxin
B5D77_RS23765 4662114..4662386 + 273 WP_106909776.1 hypothetical protein -
B5D77_RS23770 4662444..4662644 + 201 WP_079206804.1 hypothetical protein -
B5D77_RS23775 4662750..4662995 + 246 WP_002753457.1 type II toxin-antitoxin system HicB family antitoxin -
B5D77_RS23780 4662995..4663216 + 222 WP_002732388.1 type II toxin-antitoxin system HicA family toxin -
B5D77_RS23785 4663313..4664749 - 1437 WP_008199556.1 folate/biopterin family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8395.90 Da        Isoelectric Point: 11.2578

>T75288 WP_002733933.1 NZ_CP020664:4661812-4662036 [Microcystis sp. MC19]
MSELPPIAGRQVVKALGKIGYELDRQRGSHIILRQKAYPYRRITIPDHREVAKGTLRSIIRQAGLTVAEFKTLL

Download         Length: 225 bp

>T75288 NZ_CP020664:4661812-4662036 [Microcystis sp. MC19]
ATGAGTGAACTCCCTCCTATCGCTGGTCGCCAAGTCGTTAAAGCACTGGGCAAGATTGGCTACGAATTAGATCGGCAGCG
AGGAAGTCATATCATACTCAGACAAAAAGCCTATCCCTATCGACGCATCACCATCCCTGACCATCGAGAAGTCGCTAAGG
GAACGCTGAGATCTATCATTCGTCAAGCGGGATTGACAGTGGCAGAGTTTAAAACTCTCCTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7836.95 Da        Isoelectric Point: 3.9098

>AT75288 WP_008199545.1 NZ_CP020664:4661603-4661815 [Microcystis sp. MC19]
MKYRVLIEQDEDGIYVAEVPSLPGCISQGNTRFELLANIQEAIALYLESLEAHNEPIPPPISEELVEVKL

Download         Length: 213 bp

>AT75288 NZ_CP020664:4661603-4661815 [Microcystis sp. MC19]
ATGAAATATCGCGTCTTAATTGAGCAGGATGAAGATGGCATTTATGTGGCTGAAGTTCCCTCCCTACCCGGCTGTATTTC
TCAAGGCAATACCCGGTTCGAGTTACTCGCCAACATTCAGGAAGCAATTGCTTTATATCTAGAAAGCCTAGAAGCGCACA
ATGAACCGATTCCACCACCAATTTCTGAGGAACTGGTAGAGGTTAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L7ED23

Antitoxin

Source ID Structure
AlphaFold DB I4IBE8

References