Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2741813..2742279 Replicon chromosome
Accession NZ_CP020664
Organism Microcystis sp. MC19

Toxin (Protein)


Gene name hicA Uniprot ID I4GVQ6
Locus tag B5D77_RS13900 Protein ID WP_002784337.1
Coordinates 2741813..2742001 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag B5D77_RS13905 Protein ID WP_106909037.1
Coordinates 2742013..2742279 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5D77_RS13895 2738331..2741795 + 3465 WP_106909036.1 tetratricopeptide repeat protein -
B5D77_RS13900 2741813..2742001 + 189 WP_002784337.1 type II toxin-antitoxin system HicA family toxin Toxin
B5D77_RS13905 2742013..2742279 + 267 WP_106909037.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7145.39 Da        Isoelectric Point: 10.8174

>T75284 WP_002784337.1 NZ_CP020664:2741813-2742001 [Microcystis sp. MC19]
MESREIIKKPKDEGWYQVGTTGSHHHFKHPHKKGKVTVPHPKKDIPLKTLISIEKQAGIKLR

Download         Length: 189 bp

>T75284 NZ_CP020664:2741813-2742001 [Microcystis sp. MC19]
ATGGAAAGTCGAGAAATTATCAAAAAACCGAAGGATGAGGGATGGTATCAAGTAGGTACAACAGGAAGTCATCATCATTT
TAAACATCCCCATAAAAAAGGGAAAGTGACTGTTCCTCACCCTAAAAAGGATATTCCCCTTAAAACCCTAATCAGTATCG
AAAAACAAGCCGGTATTAAATTACGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9613.90 Da        Isoelectric Point: 4.1941

>AT75284 WP_106909037.1 NZ_CP020664:2742013-2742279 [Microcystis sp. MC19]
MITYLATVHKDKHSDYGVQFYDFPGCISAGETIEEAKKMATEALKGHISFMLADGDEIPTPSTLETILTDADHQDAIAFL
LIEVSVVP

Download         Length: 267 bp

>AT75284 NZ_CP020664:2742013-2742279 [Microcystis sp. MC19]
ATGATTACTTATTTAGCCACCGTTCATAAAGATAAACATAGTGATTATGGGGTACAATTTTATGACTTTCCGGGTTGTAT
TAGTGCAGGAGAAACCATCGAAGAAGCGAAAAAAATGGCAACTGAAGCCTTAAAAGGTCATATTTCCTTTATGTTGGCAG
ATGGGGACGAAATTCCCACCCCTAGCACCCTCGAAACCATTTTAACCGACGCGGATCATCAAGATGCGATCGCTTTTCTA
CTCATTGAGGTATCAGTAGTTCCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4GVQ6

Antitoxin

Source ID Structure

References