Detailed information of TA system TA075278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5722294..5722799
• Replicon: chromosome
• Accession: NZ_CP020659
• Organism: Pseudomonas aeruginosa PAK

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: Y880_RS27235
• Protein ID: WP_003083773.1
• Coordinates: 5722294..5722575 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: Y880_RS27240
• Protein ID: WP_003112628.1
• Coordinates: 5722572..5722799 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y880_RS27210	5717545..5718894	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
Y880_RS27215	5718943..5719629	+	687	WP_004351997.1	FadR family transcriptional regulator	-
Y880_RS27220	5719730..5720464	+	735	WP_003117208.1	GntR family transcriptional regulator	-
Y880_RS27225	5720668..5721054	+	387	WP_014602345.1	aegerolysin family protein	-
Y880_RS27230	5721086..5721994	-	909	WP_003083769.1	LysR family transcriptional regulator	-
Y880_RS27235	5722294..5722575	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
Y880_RS27240	5722572..5722799	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
Y880_RS27245	5722975..5723595	-	621	WP_016252837.1	hypothetical protein	-
Y880_RS27250	5723696..5724196	+	501	WP_003101228.1	LEA type 2 family protein	-
Y880_RS27255	5724269..5724610	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
Y880_RS27260	5724692..5726119	-	1428	WP_016252838.1	GABA permease	-
Y880_RS27265	5726288..5727781	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T75278 WP_003083773.1 NZ_CP020659:c5722575-5722294 [Pseudomonas aeruginosa PAK]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T75278 NZ_CP020659:c5722575-5722294 [Pseudomonas aeruginosa PAK]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT75278 WP_003112628.1 NZ_CP020659:c5722799-5722572 [Pseudomonas aeruginosa PAK]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT75278 NZ_CP020659:c5722799-5722572 [Pseudomonas aeruginosa PAK]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: Q9I707