Detailed information of TA system TA075260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 1188163..1188982
• Replicon: chromosome
• Accession: NZ_CP020657
• Organism: Klebsiella sp. M5al

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: BWI76_RS05655
• Protein ID: WP_004132607.1
• Coordinates: 1188163..1188420 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: BWI76_RS05660
• Protein ID: WP_004132606.1
• Coordinates: 1188431..1188982 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BWI76_RS05640	1183930..1184706	-	777	WP_004132612.1	Uxu operon transcriptional regulator	-
BWI76_RS05645	1184843..1186318	-	1476	WP_004132611.1	fructuronate reductase	-
BWI76_RS05650	1186395..1187579	-	1185	WP_004132609.1	mannonate dehydratase	-
BWI76_RS05655	1188163..1188420	+	258	WP_004132607.1	YjhX family toxin	Toxin
BWI76_RS05660	1188431..1188982	+	552	WP_004132606.1	N-acetyltransferase	Antitoxin
BWI76_RS05665	1189000..1190628	+	1629	WP_064371487.1	SAM-dependent methyltransferase	-
BWI76_RS05670	1190732..1192072	-	1341	WP_049088521.1	carbohydrate porin	-
BWI76_RS05675	1192196..1193593	-	1398	WP_004132593.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T75260 WP_004132607.1 NZ_CP020657:1188163-1188420 [Klebsiella sp. M5al]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T75260 NZ_CP020657:1188163-1188420 [Klebsiella sp. M5al]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATGCATC
AGGCCGCGTCACTTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTATCGCATCAATACCACCGGGCTGAATAATGTCCGCGCA
CAGCTGGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT75260 WP_004132606.1 NZ_CP020657:1188431-1188982 [Klebsiella sp. M5al]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT75260 NZ_CP020657:1188431-1188982 [Klebsiella sp. M5al]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCAATGACATTCTCCATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTTGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGGGCTTATCCGTCACGGCATTGAGCA
GTTGAAAGCCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCATGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGCGCTCAAAGCCTGCTGGATGCTGCAGCCGCTTTCATCT
CAGCCGCTGGGACGAACGGGTCAAATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA