Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2531013..2531527 Replicon chromosome
Accession NZ_CP020656
Organism Staphylococcus aureus strain K5

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag B7R57_RS13275 Protein ID WP_000581793.1
Coordinates 2531318..2531527 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag B7R57_RS13270 Protein ID WP_000138932.1
Coordinates 2531013..2531306 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R57_RS13240 2526475..2527116 + 642 WP_000483155.1 thiamine phosphate synthase -
B7R57_RS13245 2527202..2528074 + 873 WP_000725802.1 membrane protein insertase YidC -
B7R57_RS13260 2528688..2529335 - 648 WP_001187628.1 HD domain-containing protein -
B7R57_RS13265 2529363..2530847 - 1485 WP_000571549.1 cardiolipin synthase -
B7R57_RS13270 2531013..2531306 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
B7R57_RS13275 2531318..2531527 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
B7R57_RS13280 2531655..2531792 + 138 WP_000828354.1 hypothetical protein -
B7R57_RS13285 2532055..2533257 - 1203 WP_001109939.1 rod shape-determining protein RodA -
B7R57_RS13290 2533575..2534645 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
B7R57_RS13295 2534660..2536018 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T75255 WP_000581793.1 NZ_CP020656:2531318-2531527 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T75255 NZ_CP020656:2531318-2531527 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT75255 WP_000138932.1 NZ_CP020656:2531013-2531306 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT75255 NZ_CP020656:2531013-2531306 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References