Detailed information of TA system TA075251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2261137..2261669
• Replicon: chromosome
• Accession: NZ_CP020656
• Organism: Staphylococcus aureus strain K5

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: B7R57_RS11695
• Protein ID: WP_001103944.1
• Coordinates: 2261349..2261669 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: B7R57_RS11690
• Protein ID: WP_001058486.1
• Coordinates: 2261137..2261346 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7R57_RS11655	2256383..2256667	+	285	WP_000917289.1	co-chaperone GroES	-
B7R57_RS11660	2256743..2258359	+	1617	WP_000240642.1	chaperonin GroEL	-
B7R57_RS11665	2258428..2259600	-	1173	WP_104930258.1	site-specific integrase	-
B7R57_RS11670	2259614..2260288	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
B7R57_RS11675	2260461..2260679	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
B7R57_RS11680	2260684..2261001	+	318	WP_069724350.1	helix-turn-helix domain-containing protein	-
B7R57_RS11685	2260998..2261144	+	147	WP_000708434.1	hypothetical protein	-
B7R57_RS11690	2261137..2261346	+	210	WP_001058486.1	hypothetical protein	Antitoxin
B7R57_RS11695	2261349..2261669	+	321	WP_001103944.1	DUF1474 family protein	Toxin
B7R57_RS11700	2261736..2262605	+	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
B7R57_RS11705	2262619..2264319	+	1701	WP_000447470.1	DUF927 domain-containing protein	-
B7R57_RS11710	2264649..2265029	+	381	WP_020977426.1	hypothetical protein	-
B7R57_RS11715	2265026..2265667	+	642	WP_101766726.1	pathogenicity island protein	-
B7R57_RS11720	2266184..2266525	+	342	WP_104930259.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2256383..2268699	12316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T75251 WP_001103944.1 NZ_CP020656:2261349-2261669 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T75251 NZ_CP020656:2261349-2261669 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT75251 WP_001058486.1 NZ_CP020656:2261137-2261346 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT75251 NZ_CP020656:2261137-2261346 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9