Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 935432..935909 Replicon chromosome
Accession NZ_CP020656
Organism Staphylococcus aureus strain K5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B7R57_RS04725 Protein ID WP_000052076.1
Coordinates 935721..935909 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B7R57_RS04720 Protein ID WP_001059690.1
Coordinates 935432..935692 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R57_RS04685 930828..931544 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
B7R57_RS04690 931692..932114 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
B7R57_RS04695 932509..933003 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
B7R57_RS04700 933159..933776 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
B7R57_RS04705 933900..934430 - 531 WP_173677721.1 phosphoglycerate mutase family protein -
B7R57_RS04710 934655..934891 + 237 WP_000368687.1 hypothetical protein -
B7R57_RS04715 934888..935091 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B7R57_RS04720 935432..935692 + 261 WP_001059690.1 hypothetical protein Antitoxin
B7R57_RS04725 935721..935909 + 189 WP_000052076.1 hypothetical protein Toxin
B7R57_RS04730 936097..936666 + 570 WP_001106652.1 hypothetical protein -
B7R57_RS04735 936754..937038 + 285 WP_001004401.1 hypothetical protein -
B7R57_RS04740 937100..937318 + 219 WP_000005887.1 hypothetical protein -
B7R57_RS04745 937814..938014 - 201 WP_001059082.1 cold-shock protein -
B7R57_RS04750 938371..939057 - 687 WP_001641381.1 thermonuclease family protein -
B7R57_RS04755 939398..939874 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 932509..995670 63161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T75246 WP_000052076.1 NZ_CP020656:935721-935909 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75246 NZ_CP020656:935721-935909 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75246 WP_001059690.1 NZ_CP020656:935432-935692 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75246 NZ_CP020656:935432-935692 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References