Detailed information of TA system TA075241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504849..1505510
• Replicon: chromosome
• Accession: NZ_CP020655
• Organism: Bordetella parapertussis strain A747

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: B7P01_RS07110
• Protein ID: WP_003812073.1
• Coordinates: 1504849..1505274 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B7P01_RS07115
• Protein ID: WP_003812071.1
• Coordinates: 1505271..1505510 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P01_RS07090	1500663..1501640	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
B7P01_RS07095	1501661..1502173	-	513	WP_010928017.1	hypothetical protein	-
B7P01_RS07100	1502672..1504177	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
B7P01_RS07105	1504275..1504739	-	465	WP_003812075.1	MarR family transcriptional regulator	-
B7P01_RS07110	1504849..1505274	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
B7P01_RS07115	1505271..1505510	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
B7P01_RS07120	1505584..1506426	-	843	WP_010928019.1	AraC family transcriptional regulator	-
B7P01_RS07125	1506564..1507109	+	546	WP_010928020.1	peroxidase-related enzyme	-
B7P01_RS07130	1507168..1507680	+	513	WP_003812062.1	redoxin domain-containing protein	-
B7P01_RS07135	1507761..1507994	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
B7P01_RS07140	1507991..1508551	+	561	WP_010928021.1	DUF488 domain-containing protein	-
B7P01_RS07145	1508629..1509675	+	1047	WP_010928022.1	Dyp-type peroxidase	-
B7P01_RS07150	1509672..1510475	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T75241 WP_003812073.1 NZ_CP020655:c1505274-1504849 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T75241 NZ_CP020655:c1505274-1504849 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT75241 WP_003812071.1 NZ_CP020655:c1505510-1505271 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT75241 NZ_CP020655:c1505510-1505271 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5