Detailed information of TA system TA075240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381712..3382348
• Replicon: chromosome
• Accession: NZ_CP020654
• Organism: Bordetella parapertussis strain B337

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: B7P09_RS15955
• Protein ID: WP_010928914.1
• Coordinates: 3381712..3381894 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: B7P09_RS15960
• Protein ID: WP_010928915.1
• Coordinates: 3381956..3382348 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P09_RS15930	3377286..3377963	+	678	WP_010928910.1	HAD-IA family hydrolase	-
B7P09_RS15935	3378181..3379368	+	1188	WP_010928911.1	MFS transporter	-
B7P09_RS15945	3379943..3381163	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
B7P09_RS15955	3381712..3381894	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7P09_RS15960	3381956..3382348	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7P09_RS15965	3382621..3383530	-	910	Protein_3138	LysR family transcriptional regulator	-
B7P09_RS15970	3383655..3384629	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
B7P09_RS15975	3384664..3385023	+	360	WP_010928917.1	hypothetical protein	-
B7P09_RS15980	3385090..3386262	+	1173	WP_010928918.1	thiolase domain-containing protein	-
B7P09_RS15985	3386266..3386692	+	427	Protein_3142	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379943..3381163	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T75240 WP_010928914.1 NZ_CP020654:3381712-3381894 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T75240 NZ_CP020654:3381712-3381894 [Bordetella parapertussis]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT75240 WP_010928915.1 NZ_CP020654:3381956-3382348 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT75240 NZ_CP020654:3381956-3382348 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0