Detailed information of TA system TA075229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2899110..2899771
• Replicon: chromosome
• Accession: NZ_CP020651
• Organism: Bordetella bronchiseptica strain D755

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: B7P00_RS13645
• Protein ID: WP_003812073.1
• Coordinates: 2899346..2899771 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B7P00_RS13640
• Protein ID: WP_003812071.1
• Coordinates: 2899110..2899349 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P00_RS13605	2894145..2894948	-	804	WP_003812055.1	bacteriocin family protein	-
B7P00_RS13610	2894945..2895991	-	1047	WP_003812057.1	Dyp-type peroxidase	-
B7P00_RS13615	2896069..2896629	-	561	WP_033452199.1	DUF488 domain-containing protein	-
B7P00_RS13620	2896626..2896859	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
B7P00_RS13625	2896940..2897452	-	513	WP_003812062.1	redoxin domain-containing protein	-
B7P00_RS13630	2897511..2898056	-	546	WP_033452198.1	peroxidase-related enzyme	-
B7P00_RS13635	2898194..2899036	+	843	WP_003812068.1	AraC family transcriptional regulator	-
B7P00_RS13640	2899110..2899349	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
B7P00_RS13645	2899346..2899771	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
B7P00_RS13650	2899881..2900345	+	465	WP_003812075.1	MarR family transcriptional regulator	-
B7P00_RS13655	2900443..2901948	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
B7P00_RS13660	2902447..2902959	+	513	WP_003812080.1	hypothetical protein	-
B7P00_RS13665	2902980..2903957	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T75229 WP_003812073.1 NZ_CP020651:2899346-2899771 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T75229 NZ_CP020651:2899346-2899771 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCTCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT75229 WP_003812071.1 NZ_CP020651:2899110-2899349 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT75229 NZ_CP020651:2899110-2899349 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5