Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 3256864..3257395 Replicon chromosome
Accession NZ_CP020649
Organism Bordetella bronchiseptica strain E010

Toxin (Protein)


Gene name shpA Uniprot ID A0A0C6P1L1
Locus tag B7P10_RS15445 Protein ID WP_015064047.1
Coordinates 3256864..3257130 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag B7P10_RS15450 Protein ID WP_003816743.1
Coordinates 3257117..3257395 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P10_RS15420 3251991..3252263 + 273 WP_003812615.1 hypothetical protein -
B7P10_RS15425 3252302..3253012 - 711 WP_003812617.1 aquaporin Z -
B7P10_RS15430 3253123..3253755 - 633 WP_003812619.1 PAS domain-containing protein -
B7P10_RS15435 3254152..3255030 + 879 WP_003812621.1 tripartite tricarboxylate transporter substrate binding protein -
B7P10_RS15440 3255092..3256633 + 1542 WP_003812624.1 M81 family metallopeptidase -
B7P10_RS15445 3256864..3257130 + 267 WP_015064047.1 BrnT family toxin Toxin
B7P10_RS15450 3257117..3257395 + 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
B7P10_RS15460 3257696..3258352 - 657 WP_015064048.1 phosphoribosylanthranilate isomerase -
B7P10_RS15465 3258367..3260034 - 1668 WP_003812634.1 TRAP transporter large permease subunit -
B7P10_RS15470 3260037..3260666 - 630 WP_003812635.1 TRAP transporter small permease subunit -
B7P10_RS15475 3260878..3261972 - 1095 WP_003812637.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10090.52 Da        Isoelectric Point: 9.4798

>T75222 WP_015064047.1 NZ_CP020649:3256864-3257130 [Bordetella bronchiseptica]
MDITYDPAKNDKNIADRGLSFELVRGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

>T75222 NZ_CP020649:3256864-3257130 [Bordetella bronchiseptica]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGCGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT75222 WP_003816743.1 NZ_CP020649:3257117-3257395 [Bordetella bronchiseptica]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp

>AT75222 NZ_CP020649:3257117-3257395 [Bordetella bronchiseptica]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6P1L1

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References