Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2926514..2927175 Replicon chromosome
Accession NZ_CP020649
Organism Bordetella bronchiseptica strain E010

Toxin (Protein)


Gene name vapC Uniprot ID A0A807E2K1
Locus tag B7P10_RS13785 Protein ID WP_033448127.1
Coordinates 2926750..2927175 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807E2N3
Locus tag B7P10_RS13780 Protein ID WP_033448129.1
Coordinates 2926514..2926753 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P10_RS13745 2921543..2922346 - 804 WP_015063708.1 bacteriocin family protein -
B7P10_RS13750 2922343..2923389 - 1047 WP_015063707.1 Dyp-type peroxidase -
B7P10_RS13755 2923467..2924027 - 561 WP_015063706.1 DUF488 domain-containing protein -
B7P10_RS13760 2924024..2924257 - 234 WP_033447348.1 DUF2945 domain-containing protein -
B7P10_RS13765 2924339..2924851 - 513 WP_033447345.1 redoxin domain-containing protein -
B7P10_RS13770 2924910..2925455 - 546 WP_015063704.1 peroxidase-related enzyme -
B7P10_RS13775 2925599..2926441 + 843 WP_033448135.1 AraC family transcriptional regulator -
B7P10_RS13780 2926514..2926753 + 240 WP_033448129.1 Arc family DNA-binding protein Antitoxin
B7P10_RS13785 2926750..2927175 + 426 WP_033448127.1 PIN domain-containing protein Toxin
B7P10_RS13790 2927285..2927749 + 465 WP_033448125.1 MarR family transcriptional regulator -
B7P10_RS13795 2927846..2929351 - 1506 WP_033448123.1 tripartite tricarboxylate transporter permease -
B7P10_RS13800 2929850..2930362 + 513 WP_033448121.1 hypothetical protein -
B7P10_RS13805 2930382..2931356 - 975 WP_050483014.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14904.22 Da        Isoelectric Point: 5.4757

>T75221 WP_033448127.1 NZ_CP020649:2926750-2927175 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAALSVAEIQLGLARLPRGKRAETLRHEFERRILPLFMGHVLPFDA
AAADAYAAVMTQAAAAGHALDAIDGCIAATATAHGLAIATRHPARFEAAGLTAIDPWQAAV

Download         Length: 426 bp

>T75221 NZ_CP020649:2926750-2927175 [Bordetella bronchiseptica]
ATGATCCTGCTCGATACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAGACCCTGTACCTGGCCGCGCTCAGCGTGGCCGAGATCCAGCTCGGGCTGGCTCGCCTGCCGCGCGGCA
AGCGGGCCGAGACGCTGCGCCACGAATTCGAGCGGCGCATCCTGCCCCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTATGCCGCCGTCATGACGCAAGCCGCGGCGGCCGGCCATGCGCTGGACGCGATCGACGGCTGCAT
CGCCGCCACCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCACCCGGCCCGCTTCGAAGCCGCCGGGCTCACCGCCA
TCGACCCCTGGCAAGCCGCCGTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8535.74 Da        Isoelectric Point: 11.5658

>AT75221 WP_033448129.1 NZ_CP020649:2926514-2926753 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARAASFE

Download         Length: 240 bp

>AT75221 NZ_CP020649:2926514-2926753 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTGCGCGCCGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGACGGGCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGATCTGACCATCGAACGCAACCCGGCGCCCGCCCGCGCGGCCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807E2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A807E2N3

References