Detailed information of TA system TA075210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441874..2442468
• Replicon: chromosome
• Accession: NZ_CP020646
• Organism: Bordetella parapertussis strain I440

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: B7P06_RS11490
• Protein ID: WP_010928352.1
• Coordinates: 2441874..2442056 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: B7P06_RS11495
• Protein ID: WP_010928351.1
• Coordinates: 2442079..2442468 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P06_RS11470	2436877..2437617	+	741	WP_003809659.1	carbonic anhydrase	-
B7P06_RS11475	2437629..2438984	-	1356	WP_003809657.1	cytochrome c	-
B7P06_RS11480	2438995..2440764	-	1770	WP_010928353.1	GMC family oxidoreductase	-
B7P06_RS11485	2440768..2441466	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
B7P06_RS11490	2441874..2442056	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7P06_RS11495	2442079..2442468	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7P06_RS11505	2442734..2443510	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
B7P06_RS11510	2443555..2444412	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
B7P06_RS11515	2444434..2445450	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
B7P06_RS11520	2445585..2446625	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T75210 WP_010928352.1 NZ_CP020646:2441874-2442056 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T75210 NZ_CP020646:2441874-2442056 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT75210 WP_010928351.1 NZ_CP020646:2442079-2442468 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT75210 NZ_CP020646:2442079-2442468 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7