Detailed information of TA system TA075206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2877865..2878526
• Replicon: chromosome
• Accession: NZ_CP020645
• Organism: Bordetella bronchiseptica strain I943

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: B7P02_RS13515
• Protein ID: WP_003817075.1
• Coordinates: 2878101..2878526 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B7P02_RS13510
• Protein ID: WP_033455046.1
• Coordinates: 2877865..2878104 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P02_RS13475	2872894..2873697	-	804	WP_003817085.1	bacteriocin family protein	-
B7P02_RS13480	2873694..2874740	-	1047	WP_003817082.1	Dyp-type peroxidase	-
B7P02_RS13485	2874818..2875378	-	561	WP_003817081.1	DUF488 domain-containing protein	-
B7P02_RS13490	2875375..2875608	-	234	WP_033455044.1	DUF2945 domain-containing protein	-
B7P02_RS13495	2875689..2876201	-	513	WP_015041573.1	redoxin domain-containing protein	-
B7P02_RS13500	2876260..2876805	-	546	WP_004567230.1	peroxidase-related enzyme	-
B7P02_RS13505	2876949..2877791	+	843	WP_015041574.1	AraC family transcriptional regulator	-
B7P02_RS13510	2877865..2878104	+	240	WP_033455046.1	Arc family DNA-binding protein	Antitoxin
B7P02_RS13515	2878101..2878526	+	426	WP_003817075.1	PIN domain-containing protein	Toxin
B7P02_RS13520	2878636..2879100	+	465	WP_003812075.1	MarR family transcriptional regulator	-
B7P02_RS13525	2879205..2880710	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
B7P02_RS13530	2881209..2881721	+	513	WP_003817073.1	hypothetical protein	-
B7P02_RS13535	2881741..2882718	-	978	WP_003817071.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T75206 WP_003817075.1 NZ_CP020645:2878101-2878526 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T75206 NZ_CP020645:2878101-2878526 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCACCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8575.81 Da
• Isoelectric Point: 11.5658

>AT75206 WP_033455046.1 NZ_CP020645:2877865-2878104 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMELTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT75206 NZ_CP020645:2877865-2878104 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAACTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGAGCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6