75188

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 884250..884727 Replicon chromosome
Accession NZ_CP020619
Organism Staphylococcus aureus strain JE2

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag B7H15_RS04480 Protein ID WP_000052078.1
Coordinates 884250..884438 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B7H15_RS04485 Protein ID WP_001059690.1
Coordinates 884467..884727 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7H15_RS04450 880291..880761 + 471 WP_000824472.1 hypothetical protein -
B7H15_RS04455 881102..881788 + 687 WP_001548082.1 thermonuclease family protein -
B7H15_RS04460 882145..882345 + 201 WP_001059082.1 cold-shock protein -
B7H15_RS04465 882841..883059 - 219 WP_000005886.1 hypothetical protein -
B7H15_RS04470 883121..883405 - 285 WP_001004395.1 hypothetical protein -
B7H15_RS04475 883493..884062 - 570 WP_001106654.1 hypothetical protein -
B7H15_RS04480 884250..884438 - 189 WP_000052078.1 hypothetical protein Toxin
B7H15_RS04485 884467..884727 - 261 WP_001059690.1 hypothetical protein Antitoxin
B7H15_RS04490 885068..885271 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B7H15_RS04495 885268..885504 - 237 WP_000368687.1 hypothetical protein -
B7H15_RS04500 885729..886310 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
B7H15_RS04505 886383..887000 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
B7H15_RS04510 887155..887649 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
B7H15_RS04515 888048..888470 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B7H15_RS04520 888618..889334 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T75188 WP_000052078.1 NZ_CP020619:c884438-884250 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75188 NZ_CP020619:c884438-884250 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75188 WP_001059690.1 NZ_CP020619:c884727-884467 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75188 NZ_CP020619:c884727-884467 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References