Detailed information of TA system TA075187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1465863..1466658
• Replicon: chromosome
• Accession: NZ_CP020618
• Organism: Staphylococcus hominis subsp. hominis strain K1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: B7P03_RS07205
• Protein ID: WP_017176399.1
• Coordinates: 1466491..1466658 (+)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: B7P03_RS07200
• Protein ID: WP_002449669.1
• Coordinates: 1465863..1466462 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P03_RS07180	1461683..1463133	+	1451	Protein_1392	ABC transporter substrate-binding protein/permease	-
B7P03_RS07185	1463126..1463848	+	723	WP_087436812.1	amino acid ABC transporter ATP-binding protein	-
B7P03_RS07190	1464110..1465231	+	1122	WP_049334938.1	tRNA epoxyqueuosine(34) reductase QueG	-
B7P03_RS07195	1465233..1465703	+	471	WP_002449676.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
B7P03_RS07200	1465863..1466462	+	600	WP_002449669.1	glucosamine-6-phosphate isomerase	Antitoxin
B7P03_RS07205	1466491..1466658	+	168	WP_017176399.1	hypothetical protein	Toxin
B7P03_RS07210	1466769..1467161	+	393	WP_002449658.1	hypothetical protein	-
B7P03_RS07215	1467302..1468687	+	1386	WP_049334939.1	class II fumarate hydratase	-
B7P03_RS07220	1468766..1469590	-	825	WP_087436813.1	RluA family pseudouridine synthase	-
B7P03_RS07225	1469728..1470837	+	1110	WP_002455149.1	GAF domain-containing sensor histidine kinase	-
B7P03_RS07230	1470852..1471475	+	624	WP_002449659.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	clpP / clpC / tufA	1443071..1724298	281227

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6478.81 Da
• Isoelectric Point: 3.9837

>T75187 WP_017176399.1 NZ_CP020618:1466491-1466658 [Staphylococcus hominis subsp. hominis]
MSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 168 bp

>T75187 NZ_CP020618:1466491-1466658 [Staphylococcus hominis subsp. hominis]
ATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGGATGATTTAGAAGCATTAGG
AAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTTCAGATT
TAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22389.25 Da
• Isoelectric Point: 4.9712

>AT75187 WP_002449669.1 NZ_CP020618:1465863-1466462 [Staphylococcus hominis subsp. hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT75187 NZ_CP020618:1465863-1466462 [Staphylococcus hominis subsp. hominis]
ATGGCAATGAATTTTAAAGTATTTGAAGATAAACAACATGCAGCAGATTATGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGATTCCATTTAAACAAGGATTCTGCACCTGTATTAGATGAACTAAAAAAGTCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGATTATGATGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAACAAGTATATTCTATTAGTCTTGATGATGATGCCGAATCATTAATCAATGATAGAATTAAAACAAAAGAAAA
TAAAGGGAAACTGACTTTACAAGTTGTTTCAATTGATAACACTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AGGCACGTGAAATTATCTTAGTTGTAACTGGTGCTGAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAATTTTTTACCAGCTGATTTAAAAGTACATCGTATGGTAACTGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
AGAAGATGTTAAAGAATACTTCACAGCGAGATTTGCATAA