Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1371552..1372070 Replicon chromosome
Accession NZ_CP020618
Organism Staphylococcus hominis subsp. hominis strain K1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag B7P03_RS06610 Protein ID WP_002448674.1
Coordinates 1371861..1372070 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag B7P03_RS06605 Protein ID WP_002437530.1
Coordinates 1371552..1371845 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P03_RS06580 1366775..1367563 + 789 WP_087436805.1 hydroxyethylthiazole kinase -
B7P03_RS06585 1367566..1368204 + 639 WP_002448695.1 thiamine phosphate synthase -
B7P03_RS06590 1368293..1369162 + 870 WP_002455066.1 membrane protein insertase YidC -
B7P03_RS06595 1369220..1369867 - 648 WP_002448635.1 HD domain-containing protein -
B7P03_RS06600 1369902..1371386 - 1485 WP_087436806.1 cardiolipin synthase -
B7P03_RS06605 1371552..1371845 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
B7P03_RS06610 1371861..1372070 + 210 WP_002448674.1 heavy-metal-associated domain-containing protein Toxin
B7P03_RS06615 1372183..1372320 + 138 WP_002437525.1 hypothetical protein -
B7P03_RS06620 1372481..1373665 - 1185 WP_002455068.1 rod shape-determining protein RodA -
B7P03_RS06625 1374050..1375120 + 1071 WP_002448652.1 D-alanine--D-alanine ligase -
B7P03_RS06630 1375136..1376491 + 1356 WP_049437353.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T75185 WP_002448674.1 NZ_CP020618:1371861-1372070 [Staphylococcus hominis subsp. hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T75185 NZ_CP020618:1371861-1372070 [Staphylococcus hominis subsp. hominis]
ATGTTAAACAGTAATATTGTATTTATAGATAACATTGAAACAGAAGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACGGTATCAATCGATATAGAAAGAAATAAGATTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT75185 WP_002437530.1 NZ_CP020618:1371552-1371845 [Staphylococcus hominis subsp. hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT75185 NZ_CP020618:1371552-1371845 [Staphylococcus hominis subsp. hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATCGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTAGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACTGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References