Detailed information of TA system TA075176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1311059..1311569
• Replicon: chromosome
• Accession: NZ_CP020598
• Organism: Acinetobacter baumannii strain WKA02

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: B7L35_RS06385
• Protein ID: WP_000824257.1
• Coordinates: 1311306..1311569 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: B7L35_RS06380
• Protein ID: WP_001165438.1
• Coordinates: 1311059..1311322 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L35_RS06360	1306471..1307498	+	1028	Protein_1258	hypothetical protein	-
B7L35_RS06365	1308194..1309417	+	1224	WP_000261481.1	inovirus-type Gp2 protein	-
B7L35_RS06370	1309414..1310442	+	1029	WP_001101792.1	hypothetical protein	-
B7L35_RS06375	1310439..1310705	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
B7L35_RS06380	1311059..1311322	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
B7L35_RS06385	1311306..1311569	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
B7L35_RS06390	1311773..1312960	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-
B7L35_RS06395	1313060..1314268	-	1209	WP_025466770.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1288388..1311569	23181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T75176 WP_000824257.1 NZ_CP020598:1311306-1311569 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T75176 NZ_CP020598:1311306-1311569 [Acinetobacter baumannii]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAGGATTATGTATATTGGCAAAACCAAGACAAAAAGACTCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACCCCCTTTGATGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTGTGGAGCAGACGAATAGATGAAAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCGATAACTATCATT
TCTTGTCGTTATCACTACGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT75176 WP_001165438.1 NZ_CP020598:1311059-1311322 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT75176 NZ_CP020598:1311059-1311322 [Acinetobacter baumannii]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTCATTGATGATTCAGATGTTGC
AGTAATTACGAGAAAAGAAGGTCAACATGCAGTTGTAATGGGACAAGACTATTACAATAGTATAATGGAGACATTGCACC
TCATGTCTTCTCCAAGTAATGCAGCACACCTAGCGAAATCAATTGCAGAATTACGGGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6