Detailed information of TA system TA075173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 192623..193302
• Replicon: chromosome
• Accession: NZ_CP020598
• Organism: Acinetobacter baumannii strain WKA02

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: B7L35_RS01025
• Protein ID: WP_000838146.1
• Coordinates: 192623..192805 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: B7L35_RS01030
• Protein ID: WP_000966688.1
• Coordinates: 192898..193302 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L35_RS00990	188404..188772	+	369	WP_032016325.1	hypothetical protein	-
B7L35_RS00995	188774..189172	+	399	WP_009517131.1	hypothetical protein	-
B7L35_RS01000	189241..189594	+	354	WP_031958856.1	hypothetical protein	-
B7L35_RS01005	189594..190742	+	1149	WP_031958858.1	fibronectin type III domain-containing protein	-
B7L35_RS01010	190795..191712	+	918	WP_031958860.1	hypothetical protein	-
B7L35_RS01015	191782..192297	+	516	WP_001185602.1	hypothetical protein	-
B7L35_RS01025	192623..192805	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7L35_RS01030	192898..193302	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7L35_RS01035	193384..193761	+	378	WP_000720074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	159915..207026	47111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T75173 WP_000838146.1 NZ_CP020598:192623-192805 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T75173 NZ_CP020598:192623-192805 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT75173 WP_000966688.1 NZ_CP020598:192898-193302 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT75173 NZ_CP020598:192898-193302 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6