Detailed information of TA system TA075158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 770561..771240
• Replicon: chromosome
• Accession: NZ_CP020584
• Organism: Acinetobacter baumannii strain JBA13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: B7L31_RS04360
• Protein ID: WP_000838146.1
• Coordinates: 770561..770743 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: B7L31_RS04365
• Protein ID: WP_000966688.1
• Coordinates: 770836..771240 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L31_RS04315	765675..766079	+	405	WP_000247948.1	hypothetical protein	-
B7L31_RS04320	766051..766419	+	369	WP_002055488.1	hypothetical protein	-
B7L31_RS04325	766421..766819	+	399	WP_001251850.1	hypothetical protein	-
B7L31_RS04330	766821..767039	+	219	WP_070423369.1	hypothetical protein	-
B7L31_RS04335	767135..767488	+	354	WP_015451444.1	hypothetical protein	-
B7L31_RS04340	767488..768636	+	1149	WP_070423372.1	phage tail protein	-
B7L31_RS04345	768733..769650	+	918	WP_083028177.1	hypothetical protein	-
B7L31_RS04350	769720..770235	+	516	WP_038346477.1	hypothetical protein	-
B7L31_RS04360	770561..770743	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7L31_RS04365	770836..771240	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7L31_RS04370	771333..772094	+	762	WP_000910437.1	hypothetical protein	-
B7L31_RS04375	772160..772537	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	686365..785148	98783

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T75158 WP_000838146.1 NZ_CP020584:770561-770743 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T75158 NZ_CP020584:770561-770743 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT75158 WP_000966688.1 NZ_CP020584:770836-771240 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT75158 NZ_CP020584:770836-771240 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6