Detailed information of TA system TA075156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3700340..3701019
• Replicon: chromosome
• Accession: NZ_CP020581
• Organism: Acinetobacter baumannii strain SSMA17

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: B7L43_RS18360
• Protein ID: WP_000838146.1
• Coordinates: 3700340..3700522 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: B7L43_RS18365
• Protein ID: WP_000966688.1
• Coordinates: 3700615..3701019 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L43_RS18315	3695454..3695858	+	405	WP_000247948.1	hypothetical protein	-
B7L43_RS18320	3695830..3696198	+	369	WP_002055488.1	hypothetical protein	-
B7L43_RS18325	3696200..3696598	+	399	WP_001251850.1	hypothetical protein	-
B7L43_RS18330	3696600..3696818	+	219	WP_070423369.1	hypothetical protein	-
B7L43_RS18335	3696914..3697267	+	354	WP_015451444.1	hypothetical protein	-
B7L43_RS18340	3697267..3698415	+	1149	WP_070423372.1	phage tail protein	-
B7L43_RS18345	3698512..3699429	+	918	WP_000094260.1	hypothetical protein	-
B7L43_RS18350	3699499..3700014	+	516	WP_038346477.1	hypothetical protein	-
B7L43_RS18360	3700340..3700522	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7L43_RS18365	3700615..3701019	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7L43_RS18370	3701118..3701294	+	177	WP_014466185.1	hypothetical protein	-
B7L43_RS18375	3701303..3701626	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
B7L43_RS18380	3701658..3702452	+	795	WP_000720608.1	hypothetical protein	-
B7L43_RS18385	3702501..3702740	-	240	WP_000763623.1	Arc family DNA-binding protein	-
B7L43_RS18390	3702863..3703018	+	156	WP_001103649.1	Arc family DNA-binding protein	-
B7L43_RS18395	3703015..3704007	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3617192..3717237	100045

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T75156 WP_000838146.1 NZ_CP020581:3700340-3700522 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T75156 NZ_CP020581:3700340-3700522 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT75156 WP_000966688.1 NZ_CP020581:3700615-3701019 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT75156 NZ_CP020581:3700615-3701019 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6