Detailed information of TA system TA075153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1358375..1359054
• Replicon: chromosome
• Accession: NZ_CP020579
• Organism: Acinetobacter baumannii strain SAA14

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: B7L45_RS06615
• Protein ID: WP_000838146.1
• Coordinates: 1358375..1358557 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: B7L45_RS06620
• Protein ID: WP_000966688.1
• Coordinates: 1358650..1359054 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L45_RS06570	1353483..1353893	+	411	WP_070423375.1	hypothetical protein	-
B7L45_RS06575	1353865..1354233	+	369	WP_070423374.1	hypothetical protein	-
B7L45_RS06580	1354235..1354633	+	399	WP_070423373.1	hypothetical protein	-
B7L45_RS06585	1354635..1354853	+	219	WP_032001527.1	hypothetical protein	-
B7L45_RS06590	1354949..1355302	+	354	WP_015451444.1	hypothetical protein	-
B7L45_RS06595	1355302..1356450	+	1149	WP_070423372.1	phage tail protein	-
B7L45_RS06600	1356547..1357464	+	918	WP_000094260.1	hypothetical protein	-
B7L45_RS06605	1357534..1358049	+	516	WP_038346477.1	hypothetical protein	-
B7L45_RS06615	1358375..1358557	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7L45_RS06620	1358650..1359054	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7L45_RS06625	1359147..1359908	+	762	WP_000910437.1	hypothetical protein	-
B7L45_RS06630	1359974..1360351	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T75153 WP_000838146.1 NZ_CP020579:1358375-1358557 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T75153 NZ_CP020579:1358375-1358557 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT75153 WP_000966688.1 NZ_CP020579:1358650-1359054 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT75153 NZ_CP020579:1358650-1359054 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6