Detailed information of TA system TA075151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3534706..3535385
• Replicon: chromosome
• Accession: NZ_CP020578
• Organism: Acinetobacter baumannii strain SSA12

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: B7L38_RS17635
• Protein ID: WP_000838146.1
• Coordinates: 3534706..3534888 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: B7L38_RS17640
• Protein ID: WP_000966688.1
• Coordinates: 3534981..3535385 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L38_RS17590	3529820..3530224	+	405	WP_000247948.1	hypothetical protein	-
B7L38_RS17595	3530196..3530564	+	369	WP_002055488.1	hypothetical protein	-
B7L38_RS17600	3530566..3530964	+	399	WP_001251850.1	hypothetical protein	-
B7L38_RS17605	3530966..3531184	+	219	WP_070423369.1	hypothetical protein	-
B7L38_RS17610	3531280..3531633	+	354	WP_015451444.1	hypothetical protein	-
B7L38_RS17615	3531633..3532781	+	1149	WP_070423372.1	phage tail protein	-
B7L38_RS17620	3532878..3533795	+	918	WP_000094260.1	hypothetical protein	-
B7L38_RS17625	3533865..3534380	+	516	WP_038346477.1	hypothetical protein	-
B7L38_RS17635	3534706..3534888	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
B7L38_RS17640	3534981..3535385	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B7L38_RS17645	3535478..3536239	+	762	WP_000910437.1	hypothetical protein	-
B7L38_RS17650	3536305..3536682	+	378	WP_016062490.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3450421..3549293	98872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T75151 WP_000838146.1 NZ_CP020578:3534706-3534888 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T75151 NZ_CP020578:3534706-3534888 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT75151 WP_000966688.1 NZ_CP020578:3534981-3535385 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT75151 NZ_CP020578:3534981-3535385 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6