Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3357437..3358088 Replicon chromosome
Accession NZ_CP020574
Organism Acinetobacter baumannii strain 15A5

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag B6S64_RS16665 Protein ID WP_000838146.1
Coordinates 3357437..3357619 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag B6S64_RS16670 Protein ID WP_000966689.1
Coordinates 3357684..3358088 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6S64_RS16620 3352694..3353359 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
B6S64_RS16625 3353364..3353753 + 390 WP_000008492.1 hypothetical protein -
B6S64_RS16630 3353755..3354123 + 369 WP_000524231.1 hypothetical protein -
B6S64_RS16635 3354132..3354536 + 405 WP_000248324.1 hypothetical protein -
B6S64_RS16640 3354508..3354876 + 369 WP_000539752.1 hypothetical protein -
B6S64_RS16645 3354878..3355276 + 399 WP_001132270.1 hypothetical protein -
B6S64_RS16650 3355278..3355490 + 213 WP_000121166.1 hypothetical protein -
B6S64_RS16655 3355598..3356527 + 930 WP_000094300.1 hypothetical protein -
B6S64_RS16660 3356572..3357105 + 534 WP_001185622.1 hypothetical protein -
B6S64_RS16665 3357437..3357619 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
B6S64_RS16670 3357684..3358088 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B6S64_RS16675 3358169..3358570 + 402 WP_000720591.1 hypothetical protein -
B6S64_RS16680 3358631..3362596 + 3966 WP_000191304.1 tape measure protein -
B6S64_RS16685 3362714..3363055 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3327045..3381659 54614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T75148 WP_000838146.1 NZ_CP020574:3357437-3357619 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T75148 NZ_CP020574:3357437-3357619 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT75148 WP_000966689.1 NZ_CP020574:3357684-3358088 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT75148 NZ_CP020574:3357684-3358088 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References