Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 4613301..4613861 Replicon chromosome
Accession NZ_CP020570
Organism Streptomyces violaceoruber strain S21

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag B1H20_RS20185 Protein ID WP_083193052.1
Coordinates 4613301..4613579 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag B1H20_RS20190 Protein ID WP_030117648.1
Coordinates 4613583..4613861 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B1H20_RS20165 4608590..4609159 + 570 WP_030117653.1 dihydrofolate reductase family protein -
B1H20_RS20170 4609203..4610330 - 1128 WP_143672669.1 DUF397 domain-containing protein -
B1H20_RS20175 4610457..4611173 - 717 WP_030198432.1 DUF4232 domain-containing protein -
B1H20_RS20180 4611710..4613293 + 1584 WP_083193051.1 helix-turn-helix domain-containing protein -
B1H20_RS20185 4613301..4613579 - 279 WP_083193052.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B1H20_RS20190 4613583..4613861 - 279 WP_030117648.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B1H20_RS20195 4614214..4614489 + 276 WP_032772945.1 hypothetical protein -
B1H20_RS20200 4614709..4615908 + 1200 WP_083193053.1 hypothetical protein -
B1H20_RS20205 4616051..4616596 + 546 WP_083193054.1 NUDIX domain-containing protein -
B1H20_RS20210 4617271..4617693 + 423 WP_050490972.1 peptidoglycan-binding protein -
B1H20_RS20215 4617824..4618309 + 486 WP_083193055.1 hypothetical protein -
B1H20_RS20220 4618233..4618646 - 414 WP_083193056.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10631.27 Da        Isoelectric Point: 10.4146

>T75145 WP_083193052.1 NZ_CP020570:c4613579-4613301 [Streptomyces violaceoruber]
MGHATRFTPHAQRDLLKIPLPEARRILGRLADLQKALDAEDLAGFDVKPLQGHDARWRLRVGDYRAVYTVEDGRLIVWVL
AVGHRREIYRSF

Download         Length: 279 bp

>T75145 NZ_CP020570:c4613579-4613301 [Streptomyces violaceoruber]
ATGGGTCACGCCACACGATTCACACCGCACGCGCAGCGGGACCTTCTCAAGATTCCGTTGCCGGAAGCCCGCCGCATCCT
CGGCCGCCTGGCGGATCTCCAGAAGGCGCTGGACGCGGAGGATCTTGCCGGATTCGACGTCAAACCGCTCCAGGGCCACG
ACGCACGCTGGCGTCTCCGCGTGGGCGACTACCGGGCCGTTTACACCGTGGAGGACGGGCGGCTCATCGTCTGGGTGCTG
GCCGTCGGCCATCGACGCGAGATCTATCGATCCTTCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10504.68 Da        Isoelectric Point: 4.5540

>AT75145 WP_030117648.1 NZ_CP020570:c4613861-4613583 [Streptomyces violaceoruber]
MSEPVTESMAEVRKHLADVIDRARRDETPTIITRRGKSEAVLVDIDEYRRLRETAERYEDEWLNRLADKAEAEGTNGSVS
LEEMAALLRSAN

Download         Length: 279 bp

>AT75145 NZ_CP020570:c4613861-4613583 [Streptomyces violaceoruber]
ATGAGTGAGCCCGTGACCGAGTCCATGGCAGAGGTACGCAAGCACCTCGCGGACGTCATCGACCGCGCCCGCCGTGACGA
GACGCCCACGATCATCACCCGCCGAGGCAAGAGCGAAGCGGTCCTCGTCGACATCGACGAGTATCGGCGTCTGCGCGAAA
CCGCCGAGCGGTACGAGGACGAATGGCTCAACCGGCTCGCGGACAAAGCGGAGGCCGAAGGAACCAACGGATCGGTATCC
CTCGAAGAGATGGCCGCGCTCCTCCGGTCGGCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References