Detailed information of TA system TA075143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5870938..5871460
• Replicon: chromosome
• Accession: NZ_CP020569
• Organism: Streptomyces gilvosporeus strain F607

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B1H19_RS26315
• Protein ID: WP_083107220.1
• Coordinates: 5870938..5871201 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0D7CDG9
• Locus tag: B1H19_RS26320
• Protein ID: WP_030064338.1
• Coordinates: 5871194..5871460 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1H19_RS26295	5866584..5867576	+	993	WP_083107217.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
B1H19_RS26300	5867653..5868498	+	846	WP_083107218.1	ROK family protein	-
B1H19_RS38860	5868579..5868743	+	165	WP_157880161.1	hypothetical protein	-
B1H19_RS26310	5869698..5870786	+	1089	WP_083107219.1	redox-regulated ATPase YchF	-
B1H19_RS26315	5870938..5871201	-	264	WP_083107220.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B1H19_RS26320	5871194..5871460	-	267	WP_030064338.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B1H19_RS38865	5871645..5871812	+	168	WP_159028141.1	hypothetical protein	-
B1H19_RS26325	5872018..5873034	+	1017	WP_083107221.1	alpha/beta hydrolase	-
B1H19_RS26330	5873147..5873932	-	786	WP_083107222.1	PIG-L family deacetylase	-
B1H19_RS26335	5874235..5874987	+	753	WP_083107223.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-59)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10071.53 Da
• Isoelectric Point: 9.7855

>T75143 WP_083107220.1 NZ_CP020569:c5871201-5870938 [Streptomyces gilvosporeus]
VSDYRTVFRPEAQAELRKIPRDAALRILAKLTELEKDPYGFKTTALVSQPDRRRLRVGDYRVVYTLDNGELVVWVVHVGH
RSAVYET

Nucleotide

• Length: 264 bp

>T75143 NZ_CP020569:c5871201-5870938 [Streptomyces gilvosporeus]
GTGAGTGACTACCGCACCGTCTTCCGTCCCGAGGCCCAGGCCGAACTCCGCAAAATCCCACGGGACGCCGCGCTGCGCAT
CCTGGCGAAGCTGACGGAGCTGGAAAAGGATCCGTACGGCTTCAAAACCACCGCACTCGTCTCCCAGCCGGACCGCCGCC
GCCTGCGAGTCGGCGACTACCGCGTCGTCTACACCCTCGACAACGGCGAACTGGTCGTATGGGTCGTCCACGTCGGCCAC
CGTTCCGCGGTCTACGAGACCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10230.69 Da
• Isoelectric Point: 4.9473

>AT75143 WP_030064338.1 NZ_CP020569:c5871460-5871194 [Streptomyces gilvosporeus]
MTQMPIESIRDVRAHLAEVVERADRDDLPTVITRRGKEVAAVVSIEVLRKYQQWEEREINRIIDERMANRSAGIPIEDVM
KETLARSE

Nucleotide

• Length: 267 bp

>AT75143 NZ_CP020569:c5871460-5871194 [Streptomyces gilvosporeus]
ATGACCCAGATGCCCATAGAGTCCATCCGCGACGTCCGCGCGCACCTGGCCGAGGTCGTCGAGCGGGCCGACCGCGACGA
TCTGCCCACCGTCATCACCCGGCGCGGCAAGGAAGTCGCGGCCGTGGTCTCGATAGAGGTCCTGCGCAAGTACCAGCAGT
GGGAAGAGCGCGAGATCAACCGCATCATCGACGAGCGCATGGCCAACCGCTCGGCCGGTATCCCCATCGAGGACGTCATG
AAGGAGACGCTGGCGCGCAGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D7CDG9